Table 2 Classification base on the platinum response and the AUC value using the clearance of HE4 and CA125
Platinum sensitive | Platinum resistant | Sensitivity | Specificity | PPV | NPV | Accuracy | P-value | AUC | |
|---|---|---|---|---|---|---|---|---|---|
HE4 clearance | HE4 non-clearance | ||||||||
1 cycle | 55/73 (75.3%) | 10/16 (62.5%) | 62.5% | 75.3% | 35.7% | 90.2% | 73.0% | 0.018 | 0.689 |
3 cycle | 59/73 (80.8%) | 12/16 (75.0%) | 75.0% | 80.8% | 54.5% | 93.7% | 79.8% | 0.000 | 0.779 |
6 cycle | 61/73 (83.6%) | 10/16 (62.5%) | 62.5% | 83.6% | 45.5% | 91.0% | 79.8% | 0.004 | 0.730 |
CA125 clearance | CA125 non-clearance | ||||||||
1 cycle | 52/73 (71.2%) | 12/16 (75.0%) | 75.0% | 71.2% | 36.4% | 92.9% | 71.9% | 0.004 | 0.731 |
3 cycle | 69/73 (94.5%) | 6/16 (37.5%) | 37.5% | 94.5% | 60.0% | 87.3% | 84.3% | 0.046 | 0.660 |
6 cycle | 71/73 (97.3%) | 6/16 (43.8%) | 43.8% | 97.3% | 77.8% | 88.8% | 87.6% | 0.011 | 0.705 |
HE4 or CA125 clearance | Both HE4 and CA125 non-clearance | ||||||||
3 cycle of HE4 or 1 cycle of CA125 | 42/73 (57.5%) | 16/16 (100%) | 100.0% | 57.5% | 34.0% | 100.0% | 65.2% | 0.000 | 0.788 |
Both HE4 and CA125 clearance | HE4 or CA125 non-clearance | ||||||||
3 cycle of HE4 and 1 cycle of CA125 | 69/73 (94.5%) | 8/16 (50.0%) | 50.0% | 94.5% | 66.7% | 89.6% | 86.5% | 0.005 | 0.723 |