Skip to main content

Table 2 Classification base on the platinum response and the AUC value using the clearance of HE4 and CA125

From: Early clearance of serum HE4 and CA125 in predicting platinum sensitivity and prognosis in epithelial ovarian cancer

  Platinum sensitive Platinum resistant Sensitivity Specificity PPV NPV Accuracy P-value AUC
  HE4 clearance HE4 non-clearance        
1 cycle 55/73 (75.3%) 10/16 (62.5%) 62.5% 75.3% 35.7% 90.2% 73.0% 0.018 0.689
3 cycle 59/73 (80.8%) 12/16 (75.0%) 75.0% 80.8% 54.5% 93.7% 79.8% 0.000 0.779
6 cycle 61/73 (83.6%) 10/16 (62.5%) 62.5% 83.6% 45.5% 91.0% 79.8% 0.004 0.730
  CA125 clearance CA125 non-clearance        
1 cycle 52/73 (71.2%) 12/16 (75.0%) 75.0% 71.2% 36.4% 92.9% 71.9% 0.004 0.731
3 cycle 69/73 (94.5%) 6/16 (37.5%) 37.5% 94.5% 60.0% 87.3% 84.3% 0.046 0.660
6 cycle 71/73 (97.3%) 6/16 (43.8%) 43.8% 97.3% 77.8% 88.8% 87.6% 0.011 0.705
  HE4 or CA125 clearance Both HE4 and CA125 non-clearance       
3 cycle of HE4 or 1 cycle of CA125 42/73 (57.5%) 16/16 (100%) 100.0% 57.5% 34.0% 100.0% 65.2% 0.000 0.788
  Both HE4 and CA125 clearance HE4 or CA125 non-clearance        
3 cycle of HE4 and 1 cycle of CA125 69/73 (94.5%) 8/16 (50.0%) 50.0% 94.5% 66.7% 89.6% 86.5% 0.005 0.723