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Table 2 Results of immunohistochemistry on MMP-14 in ovarian cancer

From: The role of MMP-14 in ovarian cancer: a systematic review

Author Tumour samples Selection of samples Years Country Scoring system Number of patients or samples Result MMP-14 Percentage positive Conclusion
Sakata et al. [56] Primary tumours Selection from archive UHa n.m Japan 0–5% = 0, 5–50% = 1, > 50% = 2 114 0 benign, 5 borderline, 59 malignant 76% More MMP-14 expression in tumours with lymphnode metastasis
Torng et al. [64] Primary tumours, serous and endometroid Selection from archive UHa 1993–2000 Taiwan    positive, numbers n.m.b   Expression MMP-14 and MMP-2 correlates
Kamat et al. [57] Primary tumours Selection from archive UHa 1990–2000 USA Overall Score 90 90 epithelial 100, moderate 56%, strong 44% HRc epithelial MMP-14 2,52 (1.30–4.88)
        87 stromal 97 (62% low, 38% high) HRc stromal MMP-14 1,30 (1.03–3.39)
          Both MMP-14 epithelial and stromal expression correlates with survival
Lin et al. [59] Primary tumours Selection from archive UHa n.m USA   77   44% epithelial expression Strong epithelial MMP-14 expression > 3 risk of death p 0.003
         40% stromal expression  
Barbolina et al. [38] Primary tumours Selection from archive UHa n.m USA   149   78%, 52% high, 94% in clear cell carcinomas No relation with stage
Adley et al. [26]d Primary tumours Selection from archive UHa 1999–2003 USA   143 77 54 32/70 serous, 23/44 endometroid, 5/9 mucinous, 17/18 clear cell
Paulsen et al. [63] Primary serous borderline tumours and implants Selection from Cancer Registry (total 632) 1985–1995 Norway   Serous borderline tumours 7 moderate, 33 strong/44, 4 weak, 8 moderate, 42 strong/55   No difference between group with and without implants, all 7 recurrences positive
Brun et al. [60] Primary serous and mucinous tumours Selection from archive UHa 2001–2006 France HSCORE Serous 115 benign/borderline 99/95, malignant 134  
       Mucinous 44   
Kato and Motoyama [65] Primary clear cell and serous carcinomas Selection from archive UHa 1997–2007 Japan   30 clear cell carcinomas 22 73 No relation with stage or survival
       30 serous carcinomas 1 3  
Wang et al. [78] Primary tumours and metastasis Selection from archive UHa 2001–2006 China     positive, numbers n.m.c Colocalization with uPA, numbers not given
Moss et al. [32] Primary tumours and metastasis Selection from archive UHa n.m.b USA 0–3 15 serous primary 5 weak, 9 moderate, 1 strong 67  
       15 serous metastasis 4 weak, 9 moderate, 2 strong 73 Only 2 metastasis had less expression than the primary tumour
       2 endometroid 1 weak 50  
       2 endometroid metastasis 2 moderate 100  
Brun et al. [60] Primary tumours Consecutive series UHa FIGO III-IV 2001–2006 France HSCORE 43 primary surgery 132 epithelial/12 stromal   No independent prognosticator
       26 interval surgery 97 epithelial/8 stromal   
Bruney et al. [49] Cores of ovarian adenocarcinomas N.m.b n.m USA   50 positive, numbers n.m.b   Inverse relationship with MUC16/CA 125
Nakayama et al. [74] Primary tumours Selection from archive UHa 2005–2011 Japan   68 12 18  
Trudel et al. [79] Primary tumours Selection from archive UHa 1993–2006 Canada Visual score HSCORE 160/170 105 66 No independent prognosticator
Bruney et al. [48]e Cores of ovarian adenocarcinomas N.m.b n.m USA   46 positive, numbers n.m.b   
Vos et al. [61] Primary tumours Consecutive series archives teaching hospital 1997–2003 the Netherlands Overall Score 94 53 positive epithelial 56 No independent prognosticator
        49 positive stromal 52  
Vos et al. [62] Primary tumours Consecutive series archives clinical network 2007–2008 the Netherlands Overall Score 97 52 positive epithelial 54  
        5 positive stromal 5  
Takahashi et al. [80] Primary tumours Selection from archive UHa 2000–2014 Japan Visual and computer-supported evaluation 107 carcinoma's, 54 borderline, 45 benign positive, numbers n.m.b   In-situ proximity assay for EphA2 and MMP-14 positive
Vos et al. [58] Primary tumours and haematogenic and lymphogenic metastasis Consecutive series archives teaching hospital 2000–2015 the Netherlands Overall Score 44 37 primary tumours positive/7 missing 37/44 Most metastasis also positive
        34 positive stromal/3 negative stromal/7 missing   
  1. aUH University Hospital
  2. bn.m. Not mentioned
  3. cHR Hazard Ratio
  4. doverlap with study by Barbolina not clear
  5. eoverlap with earlier Bruney study not clear