Skip to main content

Table 3 Univariate and multivariate cox hazards survival analysis for overall survival (OS) in epithelial ovarian cancer (EOC) patients

From: Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis

Variables Univariate regression analysis Multivariate regression analysis
HR (95% CI) P-value HR (95% CI) P-value
Age 1.327(1.089–1.948) 0.037 1.273(1.048–2.047) 0.045
BMI 1.291(0.894–1.473) 0.248 - -
Tumor size 1.561(1.210–1.826) 0.028 1.534(0.987–1.932) 0.132
Pathological grade
 G1-2 Reference - Reference -
 G3 1.356(1.130–1.825) 0.019 1.419(1.102–2.491) 0.032
Clinical stage
 I-II Reference - Reference -
 III-IV 1.938(1.420–3.487) 0.015 2.038(1.284–3.768) 0.008
Histological type
 Serous Reference - - -
 Others 1.241(0.948–1.462) 0.183 - -
Neutrophil 1.382(1.039–1.826) 0.046 1.276(0.983–1.850) 0.221
lymphocyte 0.892(0.652–1.024) 0.078 - -
Platelet 1.352(0.846–1.745) 0.328 - -
Fibrinogen 1.537(1.241–1.938) 0.025 1.420(0.995–2.018) 0.089
CA-125 1.432(1.129–1.726) 0.019 1.426(1.103–1.894) 0.038
CA-199 1.138(1.037–1.655) 0.043 1.123(0.913–1.748) 0.347
AFP 1.328(0.784–1.526) 0.361 - -
CEA 1.241(0.848–1.657) 0.497 - -
HE4 1.452(0.913–1.728) 0.142 - -
DD-INR group
 0 Reference - Reference -
 1 1.653(1.210–1.923) 0.007 1.536(1.129–2.031) 0.013
 2 2.390(1.738–2.872) 0.001 2.412(1.683–3.241) 0.009
APTT 0.783(0.482–0.929) 0.047 0.820(0.421–1.532) 0.492
TT 0.803(0.562–1.118) 0.193 - -
  1. Abbreviation: BMI body mass index, DD-INR the combination of D-dimer and International normalized ratio, AFP Alpha-fetoprotein, CEA Carcinoembryonic antigen, HE4 Human epididymis protein 4, APTT activated partial thromboplastin time, TT thrombin time, HR hazard ratio, 95% CI 95% confidence interval