Fig. 1
From: CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer
CXCL2 overexpression promotes cell resistance to cisplatin in EOC. A. CXCL2, CXCL11 and CXCL13 were identified as DEGs in GSE114206. B The mRNA expression in platinum-resistant (n = 9) compared to platinum-sensitive patients (n = 15). C-E The mRNA expression in cisplatin-sensitive and resistant EOC cell lines. F The CXCL2 protein level in cisplatin-sensitive and resistant EOC cell lines. G CXCL2 levels in serum detected by ELISA assay. H Overexpressing and knocking down efficiencies of transfection. I The cell viability assay showed overexpressing CXCL2 significantly increased IC50 in EOC cells. J The cell viability assay showed knocking down CXCL2 significantly decreased IC50 in cisplatin-resistant EOC cells. Abbreviation: DEG: differentially expressed genes, R: resistant samples; S: sensitive samples