Table 1 All of the miRNAs associated with DDP resistance in ovarian cancer
From: MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells
Study | Year | Gene | Country | Target | Samples | Results |
|---|---|---|---|---|---|---|
APOPTOSIS | ||||||
 Chen [22] | 2017 | miR-509-3p | China | BCL2 | SKOV3 and OVCAR3 cell lines | Increased DDP sensitivity. |
 Li [23] | 2019 | miR-142-5p | China | XIAP | 19 patients SKOV3 and OVCAR3 cell lines | Increased DDP sensitivity. |
 Li [24] | 2017 | miR-146a-5p | China | XIAP, BCL2L2, and BIRC5 | OVCAR3 and SKOV3 cell lines | Increased DDP sensitivity. |
 Chen [25] | 2016 | miR-509-3p | China | XIAP | SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Pang [26] | 2014 | miR-519d | China | XIAP | 7 patients A2780, SKOV3, and OVCAR3 cell lines | Increased DDP sensitivity. |
 Zhang [27] | 2013 | miR-130a | China | XIAP | A2780 cell line | Increased DDP sensitivity. |
 Chen [28] | 2016 | miR-155 | China | XIAP | SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Liu [29] | 2018 | miR-335-5p | China | BCL2L2 | OV90m A2780m and OVCAr3 cell lines | Increased DDP sensitivity. |
 Wang [30] | 2020 | miR-454 | China | BIRC5 | A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Rao [31] | 2013 | miR-106a | China | MCL1 | A2780 cell line | Increased DDP sensitivity. |
 Chen [32] | 2020 | miR-137 | China | MCL1 | OVCAR3 cell line | Increased DDP sensitivity. |
 Su [33] | 2019 | miR-142-5p | China | MCL1 | OVCAR3 and SKOV3 cell lines | Increased DDP resistance. |
 Zuo [34] | 2020 | miR-34a-5p | China | PDL1 | SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Bieg [35] | 2019 | miR-424-3p | Poland | LGALS3 | TOV21G and SKOV3 cell lines | Increased DDP sensitivity. |
 Kong [36] | 2011 | miR-125b | China | BAK1 | OV2008 cell line | Increased DDP resistance. |
 Echevarria-vargas [37] | 2014 | miR-21 | Puerto Rico | PDCD4 | A2780 and SKOV3 cell lines | Increased DDP resistance. |
 Li [38] | 2014 | miR-106a | China | PDCD4 | OVCAR3 cell line | Increased DDP resistance. |
 Wambecke [39] | 2021 | miR-27a-5p | France | UBE2N | 3 patients OAW42 and OVCAR3 cell lines | Increased DDP sensitivity. |
DNA repair and cell cycle regulation | ||||||
 Liu [40] | 2017 | miR-216b | China | PARP1 | 51 patients SKOV3 cell line | Increased DDP sensitivity. |
 Zhu [41] | 2020 | miR-770-5p | China | PARP1 | 19 patients A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Sun [42] | 2013 | miR-9 | China | BRCA1 | 113 patients A2780 and OV2008 cell lines | Increased DDP sensitivity. |
 Zhao [43] | 2016 | miR-770-5p | China | ERCC2 | 86 patients A2780 and C13 cell lines | Increased DDP sensitivity. |
 Guo [44] | 2019 | miR-98-5p | China | CDKN1A | 42 patients SKOV3 and A2780 cell lines | Increased DDP resistance. |
 Guo [45] | 2016 | miR-100 | China | mTOR and PLK1 | SKOV3 cell line | Increased DDP sensitivity. |
 Cheng [46] | 2018 | miR-409-3p | China | FIP200 | 13 patients SKOV3, OVCAR3, CAOV3, COC1, and OV1063 cell lines | Increased DDP sensitivity. |
Signaling pathways | ||||||
 Wu [47] | 2018 | miR-503 | China | PI3K | SKOV3 cell line | Increased DDP sensitivity. |
 Qin [48] | 2017 | miR-708 | China | IGF2BP1 | A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Shi [49] | 2018 | miR-205-5p | China | PTEN | OV2008 cell line | Increased DDP resistance. |
 Fu [50] | 2012 | miR-93 | China | PTEN | OVCAR3 and SKOV3 cell lines | Increased DDP resistance. |
 Li [51] | 2021 | miR-106a | China | PTEN | 12 patients SKOV3 cell line | Increased DDP resistance. |
 Yang [52] | 2020 | miR-34c | China | MET | 25 patients A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Zhang [53] | 2018 | miR-1294 | China | IGF1R | 30 patients SKOV3 cell line | Increased DDP resistance. |
 Wang [54] | 2013 | miR-199a | China | mTOR | OV2008 cell line | Increased DDP sensitivity. |
 Chen [55] | 2019 | miR-1271 | China | mTOR | SKOV3 cell line | Increased DDP sensitivity. |
 Xu [56] | 2015 | miR-497 | China | mTOR and p70S6K1 | 41 patients SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Zhang [57] | 2020 | miR-548e | China | CXCR4 | 17 patients CAOV3, OVCAR3, and SKOV3 cell lines | Increased DDP sensitivity. |
 Van jaarsveld [58] | 2015 | miR-634 | Netherlands | MAPK | A2780, OV56, OAW42, TOV112D, and TOV21G cell lines | Increased DDP sensitivity. |
 Jiang [59] | 2021 | miR-7 | China | ERK | 6 patients SKOV3 cell line | Increased DDP resistance. |
 Xu [60] | 2018 | miR-378a-3p | China | MAPK1 | 62 patients OVCAR3 and SKOV3 cell lines | Increased DDP sensitivity. |
 Zhao [61] | 2014 | miR-224-5p | China | PRKCD | 41 patients OV2008 and A2780 cell lines | Increased DDP resistance. |
 Zhou [62] | 2014 | miR-449a | China | NOTCH1 | SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Niu [63] | 2019 | miR-338-3p | China | WNT2B | 54 patients SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Dai [64] | 2019 | miR-195-5p | China | PSAT1 | 77 patients A2780, SKOV3, and HO8910 cell lines | Increased DDP sensitivity. |
Transcription factors and methylation | ||||||
 Xiao [65] | 2019 | miR-34c | China | SOX9 | 54 patients CAOV3, OVCAR3, SKOV3, and A2780 cell lines | Increased DDP sensitivity. |
 Jia [66] | 2021 | miR-491-5p | China | SOX3 | 90 patients HO8910, A2780, SKOV3, and CAOV3 cell lines | Increased DDP resistance. |
 Zhang [67] | 2020 | miR-21 | China | C-MYB | ES2 and OVCAR3 cell lines | Increased DDP sensitivity. |
 Jiang [68] | 2018 | miR-139-5p | China | C-JUN | SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Li [69] | 2019 | miR-143 | China | FOSL2 | 56 patients SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Jin [70] | 2019 | miR-210-3p | China | E2F3 | SKOV3 cell line | Increased DDP sensitivity. |
 Sun [71] | 2019 | miR-137 | USA | EZH2 | PEO1, PEO4, OV90, and IGROV1 cell lines | Increased DDP sensitivity. |
 Zhu [72] | 2016 | miR-186 | China | TWIST1 | 52 patients A2780, OV2008, OVCAR3, SKOV3, and CAOV3 cell lines | Increased DDP sensitivity. |
 Cao [73] | 2018 | miR-363 | China | SNAIL | 107 patients A2780 and OV2008 cell lines | Increased DDP sensitivity. |
 Zhang [74] | 2019 | miR-132 | China | BMI1 | SKOV3 cell line | Increased DDP sensitivity. |
 Dong [75] | 2021 | miR-205 | China | ZEB2 | A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Liu [76] | 2014 | miR-101 | China | EZH2 | 70 patients A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Zhang [77] | 2020 | miR-138-5p | China | EZH2 and SIRT1 | A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Chen [78] | 2018 | miR-139-5p | China | RNF2 | 66 patients A2780 cell line | Increased DDP sensitivity. |
 Feng [79] | 2017 | miR-199a | China | HIF1a | 23 patients OV2008 cell line | Increased DDP sensitivity. |
 Han [80] | 2017 | miR-30-5p | China | DNMT1 | A2780 cell line | Increased DDP sensitivity. |
 Xiang [81] | 2014 | miR-152 and miR-185 | China | DNMT1 | SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Liu [82] | 2019 | miR-200b/c | China | DNMT3A, DNMT3B, and SP1 | 93 patients SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
Transporters and structural factors | ||||||
 Sun [83] | 2015 | miR-186 | China | MDR1 | OVCAR and A2780 cell lines | Increased DDP sensitivity. |
 Tian [84] | 2016 | miR-595 | China | ABCB1 | 35 patients HG-SOC, HO8910, SKOV3, and ES2 cell lines | Increased DDP sensitivity. |
 Yang [85] | 2012 | miR-130a | China | ABCB1 | SKOV3 cell line | Increased DDP sensitivity. |
 Wu [86] | 2016 | miR-873 | China | ABCB1 | A2780 and OVCAR3 cell lines | Increased DDP sensitivity. |
 Xiao [87] | 2018 | miR-514 | China | ABCA1, ABCA10, and ABCF2 | SKOV3 and OVCA433 cell lines | Increased DDP sensitivity. |
 Wu [88] | 2020 | miR-194-5p | China | SLC40A1 | A2780 and COC1 cell lines | Increased DDP resistance. |
 Xiao [89] | 2018 | miR-139 | China | ATP7A/B | 37 patients CAOV3 and SNU119 cell lines | Increased DDP sensitivity. |
 Yu [90] | 2014 | miR-29 | China | COL1A1 | A2780 and SKOV3 cell lines | Increased DDP sensitivity. |
 Cui [91] | 2018 | miR-199a-3p | China | ITGB8 | 58 patients SKOV3 cell line | Increased DDP sensitivity. |
 Wu [92] | 2021 | miR-139-5p | China | SDC4 | 30 patients A2780 cell line | Increased DDP resistance. |
 Ding [93] | 2021 | miR-138-5p | China | SDC3 | 42 patients EB0405, CAOV3, and SKOV3 cell lines | Increased DDP sensitivity. |
 Han [94] | 2021 | miR-1305 | China | CNTN1 | 70 patients SKOV3 and A2780 cell lines | Increased DDP sensitivity. |
 Samuel [95] | 2016 | miR-31 | UK | KCNMA1 | A2780 and OVCAR5 cell lines | Increased DDP resistance. |
 Van jaarsveld [96] | 2013 | miR-141 | Netherlands | KEAP1 | 132 patients A2780, OV56, OAW42, TOV112D, and TOV21G cell lines | Increased DDP resistance. |