Fig. 1

Circ_0061140 was highly expressed in PTX-resistant ovarian cancer cells. (A) Circ_0061140 expression was checked by qRT-PCR in normal ovarian tissues (N = 39), PTX-sensitive ovarian cancer tissues (N = 19) and PTX-resistant ovarian cancer tissues (N = 20). (B and C) MTT assay was employed to detect cell viability after PTX treatment (0.1, 0.5, 1, 5, 10, 50 and 100 nM) in SKOV3 and HeyA8 cells and PTX-resistant SKOV3 and HeyA8 cells. (D and E) QRT-PCR was performed to determine circ_0061140 expression in IOSE-80 cells, SKOV3 and HeyA8 cells as well as PTX-resistant SKOV3 and HeyA8 cells. *P < 0.05