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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS

Fig. 4

Melatonin attenuates the PCOS like phenotype and ameliorates mitochondrial membrane damage. A The PCOS-like microstructure in the DHT-treated mice was significantly attenuated after melatonin treatment. (n = 6 in each group) B Follicle counting revealed that melatonin-treated mice had fewer antral follicles and more primordial follicles when compared with the PCOS mice (n = 6 in each group). D-F the increasing expressions of cytochrome C and decreased expression of p-Akt were attenuated after melatonin treatment (n = 6 in each group) G-I. After treated with melatonin, BAX level was significantly decreased (n = 6 in each group) (N). NS, not significant, P > 0.05, *P < 0.05, **P < 0.01

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Journal of Ovarian Research

ISSN: 1757-2215

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