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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis

Fig. 2

Circ_0000745 downregulation suppresses aggressiveness and stemness of OC cells. A, transfection efficacy of oe-circ and shRNAs in ES-2 or SK-OV-3 cells examined by RT-qPCR; B, proliferation of ES-2 and SK-OV-3 cells examined by the CCK-8 assay; C, colony formation ability of ES-2 and SK-OV-3 cells detected by the colony formation assay; D, migration ability of ES-2 and SK-OV-3 cells examined by the wound-healing assay; E, invasion ability of ES-2 and SK-OV-3 cells detected by the Transwell assay; F, protein levels of EMT-related markers in ES-2 and SK-OV-3 cells quantified by western blot assay; G, stem cell property of ES-2 and SK-OV-3 cells examined by the sphere formation assay. Data were exhibited as mean ± SD from three repetitions. Differences were analyzed by one-way ANOVA (A, C, D, E and G) or two-way ANOVA (B and F); *p < 0.05 vs. oe-NC; #p < 0.05 vs. sh-NC

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Journal of Ovarian Research

ISSN: 1757-2215

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