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Fig. 8 | Journal of Ovarian Research

Fig. 8

From: RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis

Fig. 8

Silencing of IGF2BP2 suppresses the tumorigenesis of OC cells in vivo. A, expression of circ_0000745 in SK-OV-3 cells examined by RT-qPCR; B, growth rate of xenograft tumors; C, weight of the xenograft tumors on the 35th d; D, expression of IGF2BP2 mRNA, circ_0000745, miR-3187-3p, and ERBB4 mRNA in tumor tissues examined by RT-qPCR; E, protein levels of IGF2BP2 and ERBB4 tumor tissues determined by western blot analysis. In each group, n = 5; the mean value was calculated. Data were exhibited as mean ± SD. Differences were analyzed by the two-way ANOVA (A and C) or two-way ANOVA (B, D and E); *p < 0.05 vs. sh-NC; #p < 0.05 vs. sh-IGF2BP2 + oe-NC

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Journal of Ovarian Research

ISSN: 1757-2215

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