Fig. 6

LY6K is a target of miR-324-3p. A. The target genes that may bind to miR-324-3p were predicted by retrieving the TargetScan and the differentially expressed genes screened from TCGA-OV database. B. LY6K mRNA expression levels in normal tissues and ovarian cancer tissues. C. LY6K expression levels in ovarian cancer tissues and recurrent ovarian cancer tissues. D. Online Kaplan–Meier plot of complete survival in ovarian cancer patients with low or high LY6K expression. E. LY6K expression was examined by qRT-PCR in IOSE80, SKOV3, A2780, HO8910, and OVCAR3 cells. F. TargetScan reflected the binding sites between miR-324-3p and LY6K Reporter. G. Luciferase analysis confirmed that LY6K in SKOV3 and A2780 cells was targeted by miR-324-3p. H. After transfection with mimics, qRT-PCR detected the relative expression of LY6K in ovarian cancer cells. Data were presented as mean ± SD. *p < 0.05, **p < 0.01