Table 4 Diagnostic value of single detected biomarker and combined detections for OC

protein CA125 (U/mL)

0.915

0.846–0.983

< 0.001

74.3

93.7

0.68

protein HE4 (pmol/L)

0.779

0.668–0.889

<  0.001

55.6

100.0

0.56

exosomal miR205

0.715

0.590–0.841

0.002

66.7

78.1

0.45

exosomal CA125

0.642

0.501–0.784

0.044

75.0

68.7

0.44

exosomal HE4

0.554

0.403–0.704

0.446

58.3

84.4

0.43

exosomal TCF21

0.673

0.539–0.808

0.014

47.2

59.4

0.07

protein CA125 + protein HE4

0.939

0.883–0.995

< 0.0001

96.9

83.3

0.80

protein CA125 + exosomal miR-205

0.930

0.865–0.995

<  0.0001

96.9

83.3

0.80

protein HE4 + exosomal miR-205

0.827

0.726–0.929

< 0.0001

96.9

69.4

0.66

protein CA125 + protein HE4 + exosomal miR-205

0.951

0.899–1.004

< 0.0001

100

86.1

0.86