| |
Study Groups
|
Control
|
Fertility impaired model
|
Letrozole (0.036 µg/kg)
|
SLSO (µg/kg)
|
|---|
|
0.25
|
0.64
|
1.28
|
6.4
|
12.8
|
128
|
|---|
|
Follicle count—Ovarian Reserve of Eggs
|
Primary growth (PG)
|
114 ± 8.2
|
97 ± 6.8####
|
137 ± 7****
|
99 ± 9.2
|
113 ± 8.5****
|
320 ± 6.9****
|
352 ± 5.9****
|
458 ± 7.9****
|
389 ± 9.8****
|
|
Pre-Vitellogenic (PV)
|
296 ± 8.1
|
79 ± 8.9####
|
256 ± 7.7****
|
83 ± 8.5
|
94 ± 6.3****
|
490 ± 6.9****
|
291 ± 7.9****
|
125 ± 8.4****
|
131 ± 6.6****
|
|
Early Vitellogenic (EV)
|
311 ± 8.3
|
16 ± 6.8####
|
140 ± 7.4****
|
27 ± 8.5****
|
31 ± 7.8****
|
34 ± 7.5****
|
39 ± 7.4****
|
208 ± 8.4****
|
264 ± 7.5****
|
|
Mid-Vitellogenic (MV)
|
109 ± 7.8
|
9 ± 7.6####
|
96 ± 8.4****
|
10 ± 5.8
|
20 ± 6.3****
|
31 ± 8.0****
|
28 ± 7.2****
|
49 ± 7.0****
|
64 ± 9.1****
|
|
Final growth (FG)
|
483 ± 7.6
|
12 ± 6####
|
356 ± 7.6****
|
31 ± 7.1****
|
91 ± 8.0****
|
119 ± 7.7****
|
196 ± 8.4****
|
321 ± 8.6****
|
401 ± 7.8****
|
|
Total
|
1313 ± 16.3
|
213 ± 15.3####
|
985 ± 18.0****
|
250 ± 17.0****
|
348 ± 18.4****
|
993 ± 15.6****
|
906 ± 18.4****
|
1161 ± 17.6****
|
1249 ± 19.0****
|
- Data represented as mean ± SD (n = 24). Statistical significance was arrived at using ANOVA followed by Tukey’s multiple comparison test
- #### represents p < 0.0001 compared to normal control, **** represents p < 0.0001 compared to the fertility impaired group
