Table 1 Studies included in the meta-analysis
Study | Region | No. of Patients | Mean/Median Age, y | ER⍺ Antibody Clone (Dilution) | ERβ Antibody Clone (Dilution) | Outcome Analyzed (ER Subtype) |
|---|---|---|---|---|---|---|
Aust, Bachmayr-Heyda [31] | Austria | 101 | 56 (Median) | 1D5 (1:50) | ND | PFS (ER⍺) and OS (ER⍺) |
Aust, Horak [32] | Austria | 63 | 58.3 (Median) | 1D5 (1:50) | PPG5/10 (1:20) | PFS (ERβ) and OS (ERβ) |
Battista, Mantai [33] | Germany | 107 | 61.7 (Mean) | 1D5 (NR) | ND | PFS (ER⍺) |
Burges, Brüning [34] | Germany | 100 | 60.35 (Mean) | 1D5 (1:150) | PPG5/10 (1:50) | PFS (ER⍺) and OS (ER⍺ and ERβ) |
Chan, Wei [35] | Hong Kong | 173 | 50 (Mean) | 1D5 (1:100) | EMR02 (1:30) | OS (ERβ) |
De Sousa Damião, Fujiyama Oshima [36] | Brazil | 85 | 55.8 (Mean) | 6F11 (1:50) | ND | OS (ER⍺) |
De Stefano, Zannoni [37] | Italy | 58 | 54 (Median) | 6F11 (1:100) | 14C8 (1:30) | PFS (ER⍺ and ERβ) and OS (ER⍺ and ERβ) |
de Toledo, Sarian [38] | Brazil | 152 | 55.2 (Mean) | 1D5 (1:1000) | 14C8 (1:600) | PFS (ER⍺ and ERβ) and OS (ER⍺ and ERβ) |
Feng, Wen [39] | China | 875 | 56 (Median) | SP1 (NR) | ND | PFS (ER⍺) and OS (ER⍺) |
Jönsson, Arildsen [40] | Sweden | 35 | 58 (Median) | 1D5 (1:100) | PPG5/10 (1:10) | PFS (ER⍺ and ERβ) and OS (ER⍺ and ERβ) |
Kjaer, Christensen [41] | Denmark | 720 | NR | 1D5 (1:200) | ND | OS (ER⍺) |
Lee, Rosen [42] | USA | 258 | 58.3 (Mean) | 6F11 (1:50) | ND | OS (ER⍺) |
Liew, Hsu [19] | China | 108 | 53 (Median) | 6F11 (NR) | ND | PFS (ER⍺) and OS (ER⍺) |
Llaurado Fernandez, Dawson [43] | British | 100 | 48.5 (Mean) | SP1 (NR) | ND | PFS (ER⍺) and OS (ER⍺) |
Rambau, Kelemen [44] | Calgary | 182 | 54 (Mean) | SP1 (1:50) | ND | OS (ER⍺) |
Sieh, Köbel [45] | USA | 2933 | 60.9 (Mean) | SP1 (1:25) | ND | PFS (ER⍺) |
van Kruchten, van der Marel [46] | Netherlands | 121 | 61 (Median) | SP1 (NR) | 14C8 (NR) | PFS (ER⍺ and ERβ) and OS (ER⍺ and ERβ) |