Fig. 1From: Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to presentConcept of clonal progression in cancer. Primary ancestral clone (P) has divergent evolution with early (M1) and late (M2, M4) acquisition of metastatic potential and re-seeding of metastases (M3). A high immune infiltrated microenvironment shapes clonal evolution. Pre-existent platinum resistant clones drive tumor relapseBack to article page