Table 1 A comparison of senescence-associated parameters in pEOCs senesced upon their exposure to carboplatin (CPT) and paclitaxel (PCT) in vitro and in vivo

SA-β-Gal( +)/γ-H2A.X( +) cells (%)

8

1 ± 1

73 ± 12

17 ± 2**

69 ± 10

p16-positive cells (%)

6

4 ± 2

62 ± 9

24 ± 6*

69 ± 7

p21-positive cells (%)

6

6 ± 1

42 ± 8

11 ± 8

54 ± 6

p53-positive cells (%)

6

4 ± 3

50 ± 6

7 ± 3

43 ± 5

telomere length (kbp)

6

4.4 ± 0.2

4.2 ± 0.1

4.4 ± 0.1

4.3 ± 0.1

telomerase activity (TPG)

6

2.1 ± 0.3

1.9 ± 0.3

1.8 ± 0.1

1.9 ± 0.2

γ-H2A.X-telomere colocalization (%)

10

6 ± 2

8 ± 4

6 ± 3

7 ± 1

G1 phase cells (%)

7

62 ± 4

48 ± 6

54 ± 8

41 ± 6

S phase cells (%)

7

21 ± 6

3 ± 5

19 ± 7

6 ± 1

G2/M phase cells (%)

7

17 ± 6

49 ± 1

27 ± 4

53 ± 6

subG1 cells (%)

6

0.8 ± 0.4

2.8 ± 3.4

1.5 ± 1.3

2.8 ± 1.2