Fig. 6

Effect of chemoablation and XAR™ treatment on transcripts in testes. The expression of transcripts specific to (A) pluripotent cell – Oct-4A, Sox-2, Nanog, primordial germ cell – Stella, Fragilis, (B) progenitor SSCs – total Oct-4, Sca1, germ cells – Gfra, Mvh, Dazl, c-Kit, (C) Fshr – Fshr1, Fshr3, meiotic—prohibitin, protamine, Scp3, spermatids – Cyclin B1, proliferation (Pcna), (D) maintaining redox potential – Sirt1, Sirt6, p53, and Nampt were significantly altered on XAR™ treatment. XAR™ treatment reinstated spermatogenesis in chemoablated testes. One-way ANOVA was used for statistical analysis of curative control vs curative treatment and preventive control vs preventive treatment group, ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05