Fig. 4
GalTKO primordial oocytes have marked decreases in DNA damage/repair and ISR signaling at 5D and 14D. Dots plotted represent individual primordial oocytes measured; statistics for graphs are MW-U with horizontal lines showing median values. KS test for frequency distributions. Primordial oocytes (A-C) for P-eIF2ɑ at 5D are depicted as a plotted graph, image, and frequency distribution (both graphs p = < 0.0001). D, E Show staining for ɣ-H2AX at 5D (p < 0.0001), green stars indicate clusters of primordial oocytes. F, G Show ɣ-H2AX staining at 14D (p = 0.0004); yellow arrows depict primordial oocytes. Staining intensity (H, I) for Ki67 in primordial oocytes at 14D (p = 0.0002)