Table 2 Comprehensive results for all molecular markers measured at the noted ages. Up and down arrows indicate significantly increased and decreased staining intensities compared to WT, respectively. Horizontal arrows indicate no difference between mutants and WT
Staining Intensities of GalTKO Molecular Markers Compared to WT | ||
|---|---|---|
Postnatal Age | Granulosa Cells | Primordial Oocytes |
5 Days | ↑ BiP (Primary) ↔ ɣ-H2AX (Primary) ↓ p-eIF2ɑ (Primary) ↑ Ki67 (Primary) | ↔ BiP ↓ ɣ-H2AX ↓ p-eIF2ɑ ↔ Ki67 |
14 Days | ↔ BiP ↑ ɣ-H2AX (Secondary) ↓ p-eIF2ɑ (Primary and Secondary) ↑ Ki67 (Primary) ↑ C-Caspase 3 (Secondary) | ↔ BiP ↓ ɣ-H2AX ↔ p-eIF2ɑ ↑ Ki67 |
30 Days | ↓ BiP (Primary) ↔ ɣ-H2AX ↔ p-eIF2ɑ ↔ Ki67 ↔ C-Caspase 3 (Secondary) | ↑ BiP ↑ ɣ-H2AX ↓ p-eIF2ɑ ↔ Ki67 |