Establishment of an ovarian cancer omentum metastasis-related prognostic model by integrated analysis of scRNA-seq and bulk RNA-seq

Table 2 The ρSpearman value and P-value of the 6-OMAGs correlated with pathways

Pathway	Gene	ρSpearman	P-value
Tumor Inflammation Signature	RARRES1	0.37	1.53e − 13
EMT markers	FBN1	0.75	3.62e − 69
	RARRES1	0.32	3.84e − 10
	TIMP3	0.60	1.39e − 38
ECM-related genes	FBN1	0.70	8.72e − 56
	RARRES1	0.35	4.24e − 12
	TIMP3	0.59	2.55e − 36
Angiogenesis	FBN1	0.76	1.02e − 71
	RARRES1	0.40	8.76e − 16
	TIMP3	0.59	5.05e − 36
Apoptosis	FBN1	0.54	2.48e − 29
	RARRES1	0.42	2.67e − 17
	TIMP3	0.35	4.28e − 12
Inflammatory response	FBN1	0.46	4.35e − 21
Inflammatory response	RARRES1	0.47	1.37e − 21
PI3K-AKT-mTOR pathway	FBN1	0.35	2.61e − 12
PI3K-AKT-mTOR pathway	RARRES1	0.33	6.89e − 11
P53 pathway	FBN1	0.51	7.82e − 27
	RARRES1	0.39	5.46e − 15
	TIMP3	0.37	1.27e − 13
TGFβ	FBN1	0.75	1.59e − 69
TGFβ	TIMP3	0.67	5.73e − 50
IL-10 Anti-inflammatory Signaling Pathway	FBN1	0.32	2.36e − 10
IL-10 Anti-inflammatory Signaling Pathway	RARRES1	0.43	1.21e − 18
Genes up-regulated by reactive oxygen species (ROS)	RARRES1	0.45	2.85e − 20
Collagen formation	FBN1	0.84	2.12e − 101
Collagen formation	TIMP3	0.75	7.58e − 68
Degradation of ECM	FBN1	0.83	1.35e − 96
Degradation of ECM	TIMP3	0.70	1.45e − 59
Ferroptosis	FBN1	0.47	4.32e − 22
Ferroptosis	RARRES1	0.41	1.95e − 16

ISSN: 1757-2215