Fig. 1

ANGPTL4 is highly expressed in OC and OC cell lines. High-throughput sequencing of metastatic and primary sites of OC, with the results shown as a heatmap, Red indicates upregulation and blue indicates downregulation. B Representative images of ANGPTL4 immunostaining. ANGPTL4 expression in 18 normal ovarian tissue samples and 97 OC tissue samples was determined by immunostaining. Right panel: the IHC scores for ANGPTL4 in OC and normal ovarian tissues. Analysis of variance (ANOVA) with the post hoc test was carried out, Scale bars, 200 μm. C ANGPTL4 mRNA levels in OC cells relative to Moody’s test. Data represent the means ± SD of three independent experiments. D ANGPTL4 mRNA expression data in normal ovarian tissue (n = 8) and OC tissue (n = 580) was retrieved from TCGA. E-G The overall survival (OS), progression-free interval (PFI) and disease-specific survival (DSS) rates of 377 patients with OC were compared between the low-ANGPTL4 and high-ANGPTL4 groups based on extracted clinical data from TCGA *P < 0.05, **P < 0.01, ***P < 0.001