Table 2 Univariable Cox Regression for analyzing the associated factors for complex epithelial neoplasms of the ovary

HR (95%CI)

P-value

HR (95%CI)

P-value

Year of diagnosis

2000–2001

Reference

Reference

2002–2005

0.99(0.55 ~ 1.77)

0.971

0.89(0.46 ~ 1.74)

0.739

2006–2017

0.66 (0.39 ~ 1.12)

0.121

0.51 (0.28 ~ 0.93)

0.028

Laterality

Bilateral

Reference

Reference

Left

0.61 (0.38 ~ 0.98)

0.041

0.54 (0.31 ~ 0.96)

0.035

Paired site, but no information concerning laterality

3.92 (1.94 ~ 7.93)

< 0.001

3.08 (1.3 ~ 7.29)

0.01

Right

0.36 (0.21 ~ 0.63)

< 0.001

0.41 (0.22 ~ 0.76)

0.005

Surgery status

No surgery

Reference

Reference

Surgery

0.11 (0.06 ~ 0.19)

< 0.001

0.16 (0.08 ~ 0.33)

< 0.001

Radiation therapy

No radiation

Reference

Reference

Radiation

1.04 (0.48 ~ 2.24)

0.924

0.61 (0.19 ~ 1.94)

0.404

Chemotherapy status

Chemotherapy

Reference

Reference

No chemotherapy/Unknown

1.03 (0.69 ~ 1.55)

0.883

0.86 (0.52 ~ 1.44)

0.573

Number of primary tumors

1st of 2 or more primaries

Reference

Reference

One primary only

3.28 (1.75 ~ 6.12)

< 0.001

5.13 (2.06 ~ 12.72)

< 0.001

Race

Black

Reference

Reference

Other (American Indian/AK Native, Asian/Pacific Islander)

0.3 (0.13 ~ 0.69)

0.005

0.32 (0.12 ~ 0.83)

0.019

White

0.36 (0.2 ~ 0.66)

0.001

0.34 (0.17 ~ 0.69)

0.003

Marital status at diagnosis

DSW

Reference

Reference

Married

0.53 (0.33 ~ 0.84)

0.006

0.52 (0.3 ~ 0.91)

0.021

Single

0.59 (0.35 ~ 1.01)

0.053

0.68 (0.37 ~ 1.25)

0.217

Unknown

0.71 (0.25 ~ 2)

0.512

0.53 (0.12 ~ 2.24)

0.388

Median household income

< 50,000

Reference

Reference

>=70,000

0.44 (0.23 ~ 0.84)

0.013

0.39 (0.18 ~ 0.85)

0.018

50,000-69,999

0.48 (0.26 ~ 0.91)

0.023

0.51 (0.25 ~ 1.05)

0.069

Age

<=57

Reference

Reference

>=74

4.47 (2.68 ~ 7.45)

< 0.001

2.92 (1.47 ~ 5.78)

0.002

58–73

1.65 (1.06 ~ 2.58)

0.028

1.85 (1.11 ~ 3.07)

0.018

Grade

I/II

Reference

Reference

III/IV

3.76 (2.37 ~ 5.98)

< 0.001

5.59 (3.05 ~ 10.26)

< 0.001

Unknown

3.61 (2.07 ~ 6.28)

< 0.001

4.8 (2.34 ~ 9.84)

< 0.001

Seer stage

Distant

Reference

Reference

Localized

0.14 (0.08 ~ 0.25)

< 0.001

0.09 (0.04 ~ 0.22)

< 0.001

Regional

0.31 (0.19 ~ 0.49)

< 0.001

0.31 (0.18 ~ 0.54)

< 0.001

Unknown

1.43 (0.45 ~ 4.59)

0.547

1.24 (0.3 ~ 5.14)

0.768

FIGO Stage

I

Reference

Reference

II

5.14 (2.53 ~ 10.43)

< 0.001

7.88 (2.99 ~ 20.76)

< 0.001

III

8.59 (4.47 ~ 16.5)

< 0.001

11.51 (4.63 ~ 28.61)

< 0.001

IV

11.46 (5.89 ~ 22.31)

< 0.001

18.46 (7.48 ~ 45.57)

< 0.001

Unknown

10.43 (4.82 ~ 22.59)

< 0.001

14.74 (5.23 ~ 41.55)

< 0.001

tumor size

<=59

Reference

Reference

>=177

2.63 (1.17 ~ 5.92)

0.02

3.23 (1.08 ~ 9.64)

0.036

60–176

1.74 (0.88 ~ 3.44)

0.112

2.5 (0.98 ~ 6.4)

0.056

Unknown

2.99 (1.47 ~ 6.08)

0.002

4.34 (1.66 ~ 11.4)

0.003

Lymph nodes status

negative

Reference

Reference

positive

1.28 (0.62 ~ 2.65)

0.501

1.14 (0.5 ~ 2.62)

0.755

Unknown

1.8 (0.89 ~ 3.64)

0.105

1.69 (0.75 ~ 3.78)

0.204

CA125

negative

Reference

Reference

positive

4.19 (2.25 ~ 7.8)

< 0.001

5.46 (2.69 ~ 11.11)

< 0.001

Unknown

3.93 (2.49 ~ 6.22)

< 0.001

4.07 (2.3 ~ 7.18)

< 0.001