Table 3 Multivariable Cox Regression for analyzing the associated factors for complex epithelial neoplasms of the ovary

Year of diagnosis

2000–2001

Reference

2002–2005

0.85 (0.37 ~ 1.99)

0.713

2006–2017

0.44 (0.2 ~ 0.98)

0.044

Laterality

Bilateral

Reference

Reference

Left

0.81 (0.45 ~ 1.45)

0.475

0.89(0.43 ~ 1.82)

0.746

Paired site, but no information concerning laterality

0.74 (0.27 ~ 2.03)

0.554

1.02 (0.31 ~ 3.32)

0.972

Right

0.53 (0.27 ~ 1.05)

0.068

0.75 (0.33 ~ 1.68)

0.481

Surgery status

No surgery

Reference

Reference

Surgery

0.18 (0.07 ~ 0.41)

< 0.001

0.27 (0.1 ~ 0.75)

0.011

Number of primary tumors

1st of 2 or more primaries

Reference

Reference

One primary only

2 (1.01 ~ 3.97)

0.046

2.99 (1.11 ~ 8.02)

0.03

Race

Black

Reference

Reference

Other (American Indian/AK Native, Asian/Pacific Islander)

0.35 (0.13 ~ 0.97)

0.043

0.58 (0.18 ~ 1.87)

0.362

White

0.4 (0.19 ~ 0.83)

0.014

0.43 (0.18 ~ 1.01)

0.053

Marital status at diagnosis

DSW

Reference

Reference

Married

0.6 (0.34 ~ 1.05)

0.072

0.81 (0.38 ~ 1.71)

0.582

Single

0.83 (0.41 ~ 1.64)

0.585

1.14 (0.47 ~ 2.75)

0.77

Unknown

0.34 (0.08 ~ 1.46)

0.145

0.39 (0.05 ~ 2.79)

0.349

Median household income

< 50,000

Reference

Reference

>=70,000

1.01 (0.45 ~ 2.23)

0.987

0.69 (0.27 ~ 1.77)

0.44

50,000-69,999

0.96 (0.44 ~ 2.08)

0.916

1.02 (0.41 ~ 2.54)

0.968

Age

<=57

Reference

Reference

>=74

1.57 (0.79 ~ 3.11)

0.197

0.96 (0.38 ~ 2.41)

0.924

58–73

0.88 (0.49 ~ 1.58)

0.667

1.15 (0.57 ~ 2.34)

0.696

Grade

I/II

Reference

Reference

III/IV

2.14 (1.21 ~ 3.78)

0.009

3.08 (1.45 ~ 6.54)

0.004

Unknown

2.1 (1.03 ~ 4.31)

0.042

3.48 (1.47 ~ 8.29)

0.005

Seer stage

Distant

Reference

Reference

Localized

2.19 (0.51 ~ 9.37)

0.292

1.67 (0.23 ~ 12.41)

0.615

Regional

1.19 (0.42 ~ 3.43)

0.741

1.17 (0.34 ~ 4.11)

0.801

Unknown

0.97 (0.21 ~ 4.42)

0.973

1.01 (0.16 ~ 6.39)

0.994

Stage

I

Reference

Reference

II

6.8 (1.89 ~ 24.44)

0.003

7.89 (1.32 ~ 47.2)

0.024

III

6.35 (1.51 ~ 26.8)

0.012

5.93 (0.85 ~ 41.28)

0.072

IV

6.49 (1.39 ~ 30.39)

0.018

7.49 (0.96 ~ 58.33)

0.055

Unknown

13.76 (3.65 ~ 51.85)

< 0.001

12.25 (1.74 ~ 86)

0.012

tumor size

<=59

Reference

Reference

>=177

2.48 (0.98 ~ 6.28)

0.055

3.07 (0.87 ~ 10.76)

0.08

60–176

1.28 (0.58 ~ 2.81)

0.543

1.36 (0.47 ~ 3.98)

0.57

Unknown

1.23 (0.53 ~ 2.9)

0.63

1.03 (0.32 ~ 3.28)

0.964

CA125

negative

Reference

Reference

positive

1.55 (0.65 ~ 3.69)

0.319

2.45 (0.84 ~ 7.21)

0.102

Unknown

1.93 (1.03 ~ 3.6)

0.04

2.08 (0.89 ~ 4.9)

0.093