Fig. 1

Landscape of genetic alterations and transcriptional patterns of PYAGs in ovarian cancer. A Summary of the potential biological functions of pyroptosis and their molecular regulation mechanism. B Genetic alterations of 51 PYAGs in 436 patients with ovarian cancer from TCGA-OV cohort. C CNV variation frequency of 51 PYAGs in ovarian cancer. Red dot represents the amplification frequency; blue dot represents the deletion frequency. D The location of CNV alteration of 51 PYAGs on 23 chromosomes. E Principal component analysis (PCA) for the expression of 51 PYAGs to distinguish ovarian cancer from normal samples in TCGA-OV cohort and GTEx data. Red dot: ovarian cancer samples; Blue dot: normal ovarian samples. F Expression levels of 51 PYAGs between ovarian cancer and normal ovarian tissues from TCGA-OV and GTEx cohorts. *P < 0.05; **P < 0.01; ***P < 0.001. PYAG: pyroptosis-associated genes; OV: ovarian cancer; TMB: tumor mutation burden; CNV: copy number variation; PCA: Principal component analysis