Fig. 2

Consensus clustering to identify PACs and their correlation with clinicopathological and biological characteristics. A Interaction among PYAGs in ovarian cancer shown by network. B Two PACs (k = 2) and their correlation areas calculated by consensus clustering algorithm. C Differences in the transcription profiles between the two PACs analyzed by PCA. D Survival difference between the two PACs shown by Kaplan-Meier curves based on five GEO cohorts (GSE140082, GSE17260, GSE26193, GSE32062, and GSE63885) and TCGA-OV cohort. E Differences in clinicopathologic features, expression levels of PYAGs between two PACs in OC cohorts with heatmap. F Correlation between 51 PYAGs and immune cells in the gathered TCGA-OV cohort by heatmap. G Activated biological pathways in two PACs visualized by heatmap through GSVA enrichment analysis. *P < 0.05; **P < 0.01; ***P < 0.001. PYAG: pyroptosis-associated genes; PAC: pyroptosis-associated cluster; OV: ovarian cancer; PCA: Principal component analysis; GSVA: Gene Set Variation Analysis; OS: overall survival