Fig. 6

Evaluating the relationship of Pyrsig score with TME and immune-related characteristics. A The abundance of 23 tumor-infiltrating immune cells in low and high Pyrsig scores with Estimate algorithm (Kruskal-Wallis H test). B, C TME score and tumor purity of different Pyrsig scores shown by vioplot. D Correlation between TME score, tumor-infiltrating immune cells and Pyrsig score shown by pheatmap. E Correlation matrix of all 22 immune cell proportions by heatmaps. F Heatmap for TME infiltrating cells and immune score based on TIMER, CIBERSORT, CIBERSORT − ABS, QUANTISEQ, MCP_counter, XCELL and EPIC algorithms in different Pyrsig scores. G Differences in the expression levels of immune checkpoints in different Pyrsig scores. *P < 0.05; **P < 0.01; ***P < 0.001