Fig. 1

Imagological and pathological examination at first admission and timeline of diagnose and treatment. A. Left: Sigmoid colon lesion on colonoscopy; Right: Rectal lesion on colonoscopy; B. Hematoxylin-eosin (H&E) image, original magnification× 200; C. Immunohistochemical staining for CK7 (+++), CDX-2 (+), SATB2 (+), Her2 (+), Ki67 (50%+), MLH1 (+), MSH2 (+), MSH6 (+) and PMS2 (+) (original magnification× 100). 4-5 μm FFPE sections were used for IHC staining, antibodies used were listed in Table 1; D. Peritoneal lesion on CT (indicated by red arrow). E. Timeline of the patient’s diagnose and treatment, PFS is for progression-free survival