Plasma metabolomic characterization of premature ovarian insufficiency

Zhou, Xing-Yu; Li, Xin; Zhang, Jun; Li, Ying; Wu, Xiao-Min; Yang, Yi-Zhen; Zhang, Xiao-Fei; Ma, Lin-Zi; Liu, Yu-Dong; Wang, Zhe; Chen, Shi-Ling

doi:10.1186/s13048-022-01085-y

Journal of Ovarian Research

Table 2 Characterization of the top 20 differential metabolites in positive/negative polarity mode

From: Plasma metabolomic characterization of premature ovarian insufficiency

Compound_ID	Name	Formula	Fold change	log2FC	VIP	P value	Up/Down
Com_19056_pos	Arachidonoyl amide	C₂₀H₃₃NO	5.852882	2.549147	3.311601	2.54E-09	up
Com_6551_pos	3-Hydroxy-3-methylbutanoic acid	C₅H₁₀O₃	0.305806	-1.70931	2.73131	7.48E-07	down
Com_2458_pos	Dihexyl nonanedioate	C₂₁H₄₀O₄	2.270675	1.183121	2.448546	2.34E-05	up
Com_10406_pos	18-HETE	C₂₀H₃₂O₃	1.904571	0.929466	2.283455	4.76E-05	up
Com_32725_pos	Lypressin Acetate	C₄₆H₆₅N₁₃O₁₂S₂	3.42008	1.77403	2.260713	0.000158	up
Com_10863_pos	7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-decahydronaphthalen-1-ol	C₁₅H₂₈O₂	4.176609	2.062332	2.209279	0.000276	up
Com_7281_pos	Nordiazepam	C₁₅H₁₁ClN₂O	2.746943	1.457827	2.086147	0.00038	up
Com_19603_pos	Wogonin	C₁₆H₁₂O₅	1.998795	0.999131	1.961295	0.001005	up
Com_26_pos	DL-Tryptophan	C₁₁H₁₂N₂O₂	0.788134	-0.34349	1.850143	0.00134	down
Com_5033_pos	N-Desmethyltramadol	C₁₅H₂₃NO₂	2.134642	1.093994	1.848938	0.001829	up
Com_8626_pos	PC (18:1e/14:1)	C₄₀H₇₈NO₇P	2.331238	1.221096	1.827355	0.001932	up
Com_416_pos	2-Hydroxycinnamic acid	C₉H₈O₃	0.802959	-0.3166	1.815953	0.002184	down
Com_1594_pos	Theophylline	C₇H₈N₄O₂	0.551395	-0.85884	1.826479	0.002225	down
Com_7482_pos	Vanillin	C₈H₈O₃	0.507377	-0.97887	1.877203	0.002407	down
Com_6942_pos	2-(2-oxo-2-{[2-(2-oxo-1-imidazolidinyl)ethyl]amino}ethoxy)acetic acid	C₉H₁₅N₃O₅	1.703716	0.768685	1.701999	0.003268	up
Com_27637_pos	Lenalidomide	C₁₃H₁₃N₃O₃	1.834114	0.875084	1.704982	0.003655	up
Com_2551_pos	Anacardic acid	C₂₂H₃₆O₃	1.506996	0.591675	1.811478	0.003867	up
Com_1910_pos	Ethyl chrysanthemumate	C₁₂H₂₀O₂	1.551453	0.63362	1.707027	0.004293	up
Com_6799_pos	6-Methoxy-2-naphthoic acid	C₁₂H₁₀O₃	3.988188	1.995733	1.687129	0.004703	up
Com_11318_pos	(2 S)-2-(2-hydroxypropan-2-yl)-2 H,3 H,7 H-furo[3,2-g]chromen-7-one	C₁₄H₁₄O₄	0.77809	-0.36199	1.76194	0.004857	down
Com_4006_neg	GM3 d36:1; [M-H]-	C₅₉H₁₀₈N₂O₂₁	10.5212	3.395227	2.89096	1.16E-06	up
Com_5032_neg	Cystine	C₆H₁₂N₂O₄S₂	0.643636	-0.63568	1.87981	5.61E-05	down
Com_2157_neg	L-Aspartic acid	C₄H₇NO₄	0.739742	-0.43491	1.854329	6.56E-05	down
Com_2414_neg	PG (16:0/18:1)	C₄₀H₇₇O₁₀P	19.33564	4.273191	2.267279	6.84E-05	up
Com_1106_neg	LPA 18:0	C₂₁H₄₃O₇P	0.646888	-0.62841	1.842277	7.03E-05	down
Com_2079_neg	Hexanoic acid	C₆H₁₂O₂	0.693318	-0.52841	1.714559	0.000266	down
Com_2027_neg	L-Threonic acid	C₄H₈O₅	0.731709	-0.45066	1.691488	0.000323	down
Com_8027_neg	7-Hydroxy-3,4-dihydrocarbostyril	C₉H₉NO₂	0.479844	-1.05936	1.818085	0.000456	down
Com_282_neg	Uric acid	C₅H₄N₄O₃	0.780041	-0.35838	1.631659	0.000501	down
Com_5948_neg	Daidzein	C₁₅H₁₀O₄	0.513087	-0.96272	1.670357	0.000862	down
Com_6265_neg	Undecanoic acid	C₁₁H₂₂O₂	0.744988	-0.42471	1.638692	0.000888	down
Com_8167_neg	N-Acetyl-aspartic acid	C₆H₉NO₅	0.718234	-0.47747	1.594997	0.000939	down
Com_1957_neg	5-amino-1-phenyl-1 H-pyrazole-4-carbonitrile	C₁₀H₈N₄	0.619616	-0.69055	1.526146	0.001222	down
Com_9084_neg	(5ξ,9ξ)-17-Hydroxykaur-15-en-19-oic acid	C₂₀H₃₀O₃	0.812237	-0.30003	1.547688	0.001713	down
Com_2039_neg	Lignoceric Acid	C₂₄H₄₈O₂	1.472289	0.55806	1.915449	0.00181	up
Com_3369_neg	PC (18:0e/18:2)	C₄₄H₈₆NO₇P	0.208414	-2.26248	1.815235	0.002232	down
Com_3826_neg	Methionine	C₅H₁₁NO₂S	0.758644	-0.39851	1.53752	0.002317	down
Com_518_neg	LPE 18:0	C₂₃H₄₈NO₇P	0.749874	-0.41528	1.482862	0.002971	down
Com_819_neg	LPC 18:2	C₂₆H₅₀NO₇P	0.61738	-0.69577	1.46772	0.003112	down
Com_1334_neg	DL-β-Leucine	C₆H₁₃NO₂	0.782392	-0.35404	1.462225	0.003406	down

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