Skip to main content
Fig. 2 | Journal of Ovarian Research

Fig. 2

From: GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway

Fig. 2

GIMAP7 shRNA relieves the symptoms of PCOS rats. A-H Sprague–Dawley rats (n = 6 per group) were injected with DHEA for constructing PCOS animal models, and then injected with lentivirus carrying shNC or shGIMAP7. The fasting blood-glucose (A), insulin tolerance tests (ITTs) (B), and homeostasis model assessment-insulin resistance (HOMA-IR) scores (C) were analysed in rats of each group. D Representative images of H&E staining show the histopathological changes of ovarian tissues. The serum LH (E), FSH (F), LH/FSH ratio (G), testosterone (H), and estradiol (I) were analysed using ELISA kits. J The representative oestrous cycles (D, dioestrus; P, proestrus; E, 0estrus; M, metestrus). Differences among multiple groups were analysed using a one-way analysis of variance. *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page

Journal of Ovarian Research

ISSN: 1757-2215

Contact us