Fig. 4

Silencing NUF2 inhibits OC progression in vivo. A SKOV3 cells were subcutaneously injected into the right flanks of BALB/c-nu mice. Mice were treated with PBS, si-control or modified si-NUF2. The sacrificed nude mice were photographed at 17 days after transplantation. B Tumors were derived from the nude mice of each group. C Tumor volume and weight were measured. Values are expressed as the mean ± SE. 2-tailed Student t test was used to determine significance. D Representative IHC images of tumors from nude mice for Ki-67 expression. Histograms (right) showed the number of Ki-67 positive cells. Values are expressed as the mean ± SE. 2-tailed Student t test was used to determine significance. *P < 0.05