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Table 1 Demographic analysis of the LHOTD tertile groups with agonist and antagonist regimens

From: LH level on ovulation trigger day has a different impact on the outcomes of agonist and antagonist regimens during in vitro fertilization

Variables

Agonist regimen

Antagonist regimen

T1 (< 0.56)

N = 2113

T2 (0.56–0.84)

N = 2159

T3 (> 0.84)

N = 2186

P-value

T1 (< 1.98)

N = 956

T2 (1.98–3.61)

N = 959

T3 (> 3.61)

N = 961

P-value

Age, years

31.20 ± 4.19 a

30.91 ± 4.05 a

30.75 ± 4.31 b

0.002

31.83 ± 5.10 a

32.90 ± 5.21 b

33.62 ± 5.01 c

 < 0.001

BMI

22.32 ± 2.72

22.04 ± 2.70

21.80 ± 2.63

 < 0.001

22.10 ± 2.82 a

22.36 ± 2.71 a, b

22.50 ± 2.73 b

0.006

AMH, ng/mL

3.14 (2.06–4.69) a

3.12 (2.08–4.56) a, b

3.04 (1.98–4.40) b

0.037

2.64 (1.47–5.10) a

2.31 (1.25–4.20) b

1.88 (1.02–4.08) c

 < 0.001

AFC

10 (8–12) a

11 (8–12) a, b

11 (9–13) b

 < 0.001

10 (7–14) a

9 (6–12) b

8 (6–12) c

 < 0.001

Primary infertility, n (% of total)

878 (41.6) a

976 (45.2) b

970 (44.4) a, b

0.042

411 (43.0) a

351 (36.6) b

345 (35.9) b

0.002

Cause of female infertility, n (% of total)

 Normal (Male factor only)

273 (12.9)

297 (13.8)

314 (14.4)

0.050

131 (13.7) a

94 (9.8) b

95 (9.9) b

0.315

 Fallopian tube factors

1689 (79.9)

1667 (77.2)

1682 (76.9)

747 (78.1) a

793 (82.7) b

783 (81.5) a, b

 Endometriosis

22 (1.0)

27 (1.3)

29 (1.3)

9 (0.9)

10 (1.0)

9 (0.9)

 Other factors

5 (0.2)

7 (0.3)

7 (0.3)

5 (0.5)

3 (0.3)

6 (0.6)

 Unknown reason

86 (4.1)

88 (4.1)

78 (3.6)

40 (4.2)

37 (3.9)

42 (4.4)

 Multi factors

38 (1.8) a

73 (3.4) b

76 (3.5) b

24 (2.5)

22 (2.3)

26 (2.7)

History of parturition or miscarriage, n (% of total)

 miscarriage

475 (22.5)

484 (22.4)

488 (22.3)

0.992

218 (22.8)

232 (24.2)

244 (25.4)

0.416

 cesarean section

68 (3.2)

60 (2.8)

69 (3.2)

0.663

22 (2.3) a

38 (4.0) a, b

43 (4.5) b

0.028

 vaginal delivery

162 (7.7) a

137 (6.3) a, b

109 (5.0) b

0.001

67 (7.0)

89 (9.3)

93 (9.7)

0.081

Method of fertilization, n (% of total)

 Conventional IVF

1741 (82.4)

1783 (82.6)

1756 (80.3)

0.103

763 (79.8)

802 (83.6)

795 (82.7)

0.075

 ICSI

372 (17.6)

376 (17.4)

430 (19.7)

193 (20.2)

157 (16.4)

166 (17.3)

Indicators on the day of ovulation trigger

 Luteinizing hormone, mIU/mL

0.42 (0.33–0.49) a

0.68 (0.61–0.76) b

1.12 (0.96–1.41) c

 < 0.001

1.30 (0.93–1.64) a

2.67 (2.30–3.06) b

5.22 (4.26–7.01) c

 < 0.001

 Estradiol, pg/mL

2483 (1578–3609) a

2529 (1689–3642) a, b

2608 (1749–3657) b

0.005

2070 (1182–3207)

1974 (1188–3130)

1917 (1222–3021)

0.437

 Progesterone, ng/mL

0.92 (0.64–1.31) a

0.97 (0.68–1.33) a, b

0.99 (0.7–1.35) b

 < 0.001

0.90 (0.61–1.31) a

0.93 (0.63–1.29) a

1.03 (0.76–1.38) b

 < 0.001

 Endometrial thickness, mm

11 (9–12) a

11 (10–13) a, b

11 (10–13) b

0.010

10 (9–12)

10 (9–12)

10 (9–12)

0.886

  1. T1, T2, and T3 are the 1st, 2nd, and 3rd LHOTD tertile groups in two regimens, respectively
  2. The superscript characters a, b, and c represent pairwise comparisons between two groups of the same character, with no significant difference
  3. BMI Body mass index, AMH Anti-Müllerian hormone, AFC Antral follicular count, IVF In vitro fertilization, ICSI Intracytoplasmic sperm injection