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Table 1 Summary of the eligible studies on NLR in predicting survival treatment response, and diagnosis, in patients with ovarian cancer

From: Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR

Author, Year

Conditions of participants

Significance of marker

Cho et al. [38], 2009; Badora-Rybicka et al.[70], 2016; Wang et al. [49], 2016; Nakamura et al. [53], 2016; Miao et al. [50], 2016; Feng et al. [71], 2016; Li et al. [34], 2017; Farolfi et al. [39], 2018; Zhou et al. [51], 2018; Pinto et al. [54], 2018; Pinto et al. [54], 2018; Komura et al. [48], 2018; Kim et al. [55], 2018; Baert et al. [52], 2018; Ceran et al. [40], 2019; Yoshida et al. [36], 2019; Salman et al. [41], 2020; Henriksen et al. [43], 2020; Farolfi et al. [44], 2020; Nguyen et al. [42], 2020; John-Olabode et al. [45], 2021; Liontos et al. [46], 2021

OCP: received operations, with stage IIIC and IV received NACT, with recurrence treated with chemotherapy;

EOCP: underwent elective surgery, receiving platinum-taxane CT after surgery, in FIGO stage III-IV treated with first-line CT or in CTB, with FIGO stage IIIC underwent PDS, received NACT, received their complete primary treatment;

HGSOCP: underwent surgery (PDS);

OCCCP: underwent surgery with stage I–II

Predicting survival: OS, PFS, mortality within 100 days of the failure of final‑line CT

Ashrafganjoe et al. [56], 2016; Farolfi et al. [39], 2018; Boland et al. [58], 2019; Henriksen et al. [43], 2020; Chen et al. [60], 2020; Nguyen et al. [42], 2020; Winarno et al. [59], 2021; Sastra et al. [57], 2022

OCP: recurrent and received CT;

EOCP: underwent primary staging exploratory laparotomy, in FIGO stage III-IV treated with first-line CT or CTB; received ICB, underwent platinum CT after cytoreduction surgery;

HGSOCP: underwent surgery (PDS);

OCCCP: with IC-IV stage

Predicting treatment response: surgical outcome, efficacy of CT, early discontinuation of ICB; platinum resistance, 30-day postoperative morbidity

Yildirim et al. [62], 2014; Yildirim et al. [63], 2015; Seckin et al. [26], 2015; Polat et al. [30], 2016; Wu et al. [64], 2019; Eo et al. [65], 2018; Li et al. [66], 2021; Yun et al. [67], 2022

OCP: with documented benign and with malignant adnexal masses underwent primary surgery; patients with adnexal masses underwent surgical resection; patients had borderline, patients had benign, and patients had malignant mucinous ovarian tumors; women with sonographically detected ovarian tumor; OCP, patients with benign ovarian disease, and healthy controls;

EOCP: underwent surgery; patients with benign ovarian masses and EOCP underwent surgery

Predicting diagnosis: malignant or not, malignant degree, histotypes, benign or borderline tumors

  1. NLR Neutrophil-to-lymphocyte ratio, OCP Ovarian cancer patients, EOCP, Epithelial ovarian cancer, Patients, HGSOCP, High-grade serous ovarian carcinoma patients, OCCCP, Ovarian clear cell carcinoma patients, PDS Primary debulking surgery, CT Chemotherapy, CTB Chemotherapy with bevacizumab, NACT Neoadjuvant chemotherapy, ICB Immune checkpoint blockade, CRS Cytoreductive surgery, OS Overall survival, PFS Progression-free survival