Table 1 Patient and cycle characteristics of the strategy for managing DOR compared between fresh M-II oocytes and accumulation of vitrified M-II oocytes

Number of patients

211

229

Number of OPU

1130

229

OPU /patient Mean (SD)

5.36(2.71)

1.00(0.00)

 < 0.001*

Maternal age at ART start Mean (SD)

39.29(4.23)

38.07(3.77)

0.001*

Maternal age at ET Mean (SD)

40.23(4.30)

38.07(3.77)

 < 0.001*

AMH Mean (SD)

0.54(0.35)

0.72(0.32)

 < 0.001*

Reason for ART (%)

 DOR

211(100)

229(100)

1.00

 Male factor

81(38.4)

98(42.8)

0.347

 Tubal factor

39(18.5)

48(21.0)

0.515

 Endometriosis

52(24.6)

52(22.7)

0.633

 Unexplained or others

90(42.7)

93(40.6)

0.664

Number of total warmed or fresh M-II

2089

809

M-II oocytes /patient Mean (SD)

9.90 (4.77)

3.53 (1.57)

 < 0.001*

Number of survival warmed or fresh M-II

1791

809

Number of the fertilized egg

1317

582

Fertilization of survival and fresh egg % (SD)

75.18(20.98)

75.29(24.69)

0.958

ET Day (%)

 < 0.001*

 Day 2–3

174(82.5)

220(96.1)

 Day 4–5

37(17.5)

9(3.9)

Number of fresh ET

211

229

Number of embryos transferred Mean (SD)

2.96(0.95)

2.14(0.87)

 < 0.001*

Pregnancy /ET (%)

58(27.5)

71(31.0)

0.418

Implantation rate % (SD)

12.99(25.16)

17.47(29.52)

0.089

Miscarriage /pregnancy (%)

24(41.4)

10(14.1)

 < 0.001*

Ectopic /pregnancy (%)

1(1.7)

0(1.4)

1.00

Stillbirth /ET (%)

1(1.7)

1(1.4)

1.00

Live birth /ET (%)

32(15.2)

60(26.2)

0.004*

Number of surplus vitrified embryo embryo

248

55

Surplus vitrified embryo /patient Mean (SD)

1.18(1.80)

0.24(0.65)

 < 0.001*

Cumulative live birth /ITT (%)

43(20.4)

63(27.5)

0.081

Cumulative live birth /OPU (%)

43(3.8)

63(27.5)

 < 0.001*