Table 2 Clinical outcomes of the strategy for managing DOR according to patient’s age compared between fresh M-II oocytes and accumulation of vitrified M-II oocytes

Number of patients

28

36

38

55

57

74

88

64

Number of OPU

117

36

192

55

301

74

519

64

OPU /patient Mean (SD)

4.18 (2.13)

1

 < 0.001*

5.05 (2.68)

1

 < 0.001*

5.28 (2.32)

1

 < 0.001*

5.91 (2.97)

1

 < 0.001*

Age at ART start (y), mean (SD)

31.89 (2.11)

31.86 (2.21)

0.954

36.03 (0.79)

36.09 (0.78)

0.696

39.11 (0.75)

38.84 (0.81)

0.055

43.17 (1.90)

42.36 (1.60)

0.01*

M-II oocytes /patient Mean (SD)

8.50 (3.92)

3.64 (1.44)

 < 0.001*

10.26 (5.33)

3.91 (1.34)

 < 0.001*

10.00 (4.32)

3.64 (1.67)

 < 0.001*

10.12 (5.03)

3.03 (1.62)

 < 0.001*

Fertilization of fresh survival or M-II % (SD)

77.08 (22.51)

74.26 (24.00)

0.633

75.07 (16.25)

77.03 (22.16)

0.643

74.51 (24.18)

74.85 (23.64)

0.936

75.05 (20.37)

74.90 (28.54)

0.968

Number of fresh ET

28

36

38

55

57

74

88

64

Embryos transferred Mean (SD)

2.18 (0.82)

1.81 (0.58)

0.037*

2.58 (0.89)

2.33 (0.67)

0.123

3.02 (0.9)

2.27 (0.96)

 < 0.001*

3.33 (0.85)

2.00 (0.99)

 < 0.001

Pregnancy /ET (%)

10(35.7)

16(44.4)

0.481

18(47.4)

26(47.3)

0.993

16(28.1)

23(31.1)

0.709

14(15.9)

6(9.4)

0.239

Implantation rate % (SD)

25.00 (39.93)

30.56 (38.32)

0.574

24.78 (32.68)

26.67 (32.01)

0.782

12.28 (21.08)

15.43 (27.12)

0.471

4.55 (10.64)

4.56 (16.19)

0.996

Miscarriage /ET (%)

1(10.0)

1(6.2)

1.000

6(33.3)

2(7.7)

0.048*

9(56.2)

4(17.4)

0.011*

8(57.1)

3(50.0)

1.000

Live birth /ET (%)

8(28.6)

15(41.7)

0.279

11(28.9)

23(41.8)

0.205

7(12.3)

19(25.7)

0.057

6(6.8)

3(4.7)

0.735

Number of surplus vitrified embryo

37

16

85

19

65

17

61

3

Surplus vitrified embryo /patient Mean (SD)

1.32 (1.83)

0.44 (0.73)

0.011*

2.24 (2.60)

0.35 (0.73)

 < 0.001*

1.14 (1.44)

0.23 (0.75)

 < 0.001*

0.69 (1.36)

0.05 (0.28)

0.001*

Cumulative live birth /ITT (%)

13(46.4)

16(44.4)

0.874

15(39.5)

24(43.6)

0.689

8(14.0)

20(27.0)

0.072

7(8.0)

3(4.7)

0.520

Cumulative live birth /OPU (%)

13(11.1)

16(44.4)

 < 0.001*

15(7.8)

24(43.6)

 < 0.001*

8(2.7)

20(27.0)

 < 0.001*

7(1.3)

3(4.7)

0.086