Table 3 Clinical outcomes of the strategy for managing DOR compared between fresh oocytes and accumulated vitrified oocytes reach ≥ 10 or ≥ 15 M-II oocytes

Number of patients

229

100

31

Number of OPU

229

654

256

OPU /patient Mean (SD)

1.00(0.00)

6.54(3.04)

8.26(3.60)

 < 0.001*

 < 0.001*

Maternal age at ART start Mean (SD)

38.07(3.77)

39.75(3.78)

39.26(3.61)

 < 0.001*

0.098

AMH Mean (SD)

0.72(0.32)

0.57(0.34)

0.67(0.32)

 < 0.001*

0.376

M-II oocytes /patient Mean (SD)

3.53(1.57)

13.57(4.14)

18.61(3.79)

 < 0.001*

 < 0.001*

Fertilization of fresh and survival egg % (SD)

75.29(24.69)

71.88(18.37)

73.31(12.91)

0.215

0.662

Number of the transfer cycle

229

100

31

Number of embryos transferred Mean (SD)

2.14(0.87)

3.26(0.82)

3.26(0.86)

 < 0.001*

 < 0.001*

Pregnancy /ET (%)

71(31.0)

36(36.0)

15(48.4)

0.374

0.054

Implantation rate % (SD)

17.47(29.52)

18.08(28.58)

26.34(34.57)

0.861

0.125

Miscarriage /pregnancy (%)

10(14.1)

15(41.7)

6(40.0)

0.001*

0.030*

Stillbirth /pregnancy (%)

1(1.7)

0(0.0)

0(0.0)

1.00

1.00

Live birth /ET (%)

60(26.2)

21(21.0)

9(29.0)

0.314

0.738

Number of surplus vitrified embryo

55

179

85

Surplus vitrified embryo /patient Mean (SD)

0.24(0.65)

1.79(2.18)

2.74(2.58)

 < 0.001*

 < 0.001*

Cumulative live birth /ITT (%)

63(27.5)

26(26.0)

9(29.0)

0.777

0.859

Cumulative live birth /OPU (%)

63(27.5)

26(4.0)

9(3.5)

 < 0.001*

 < 0.001*