Effects of n-3 polyunsaturated fatty acid on metabolic status in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Zhou, Jie; Zuo, Wenting; Tan, Yong; Wang, Xudong; Zhu, Meihong; Zhang, Huili

doi:10.1186/s13048-023-01130-4

Table 1 The characteristics of included studies

From: Effects of n-3 polyunsaturated fatty acid on metabolic status in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Study	Country	Study design	Diagnostic criteria	Sample size		Diet type		Study duration (weeks)	Outcomes
Study	Country	Study design	Diagnostic criteria	Intervention group	Control group	Intervention group	Control group	Study duration (weeks)	Outcomes
Amini 2018 [20]	Iran	Randomized, double blinded	Rotterdam criteria	27	27	Fish oil n-3 PUFA supplements 2000 mg/d (Marine derived)	Paraffin oil (placebo) 100 mg/d	12	BW,BMI,hs-CRP,QUICK,FPG, FINS, HOMA-IR, TG, TC, LDL-C, HDL-C,VLDL-C
Cussons 2009 [32]	Australia	Randomized, double blinded	Rotterdam criteria	12	13	Fish oil n-3 PUFA 4000 mg/d (Marine derived)	olive oil (placebo) 4000 mg/d	8	BMI,hs-CRP,FPG, FINS, HOMA-IR, TG, TC, LDL-C, HDL-C
Ebrahimi 2017 [30]	Iran	Randomized, double blinded	Rotterdam criteria	34	34	Flaxseed oil n-3 PUFA 1000 mg/d (Plant origins) + vitamin E 400 IU/d	Placebo	12	BW,BMI,QUICK,FPG, FINS, HOMA-IR
Jamilian 2018 [33]	Iran	Randomized, double blinded	Rotterdam criteria	30	30	Fish oil n-3 PUFA 2000 mg/d (Marine derived) + vitamin E 50,000 IU/2 weeks	Placebo	12	BMI, BW, hs-CRP
Khani 2017 [19]	Iran	Randomized, double blinded	NIH criteria	43	44	n-3 PUFA supplements 2000 mg/d (360 mg EPA and 240 mg DHA) (Marine derived)	Olive oil (placebo) 2000 mg/d	24	BMI,WC,FPG, TG, TC, LDL-C, HDL-C
Mejia-Montilla 2018 [26]	Venezuela	Randomized, double blinded	Specialists Consensus	97	98	n-3 PUFA supplements 1000 mg/d (180 mg EPA and 120 mg DHA)	Paraffin oil (placebo) 1000 mg/d	12	BMI,FINS, HOMA-IR, TG, TC, LDL-C, HDL-C,Adiponectin
Mirmasoumi 2018 [21]	Iran	Randomized, double blinded	Rotterdam criteria	30	30	Flaxseed oil n-3 PUFA 2000 mg/d (Plant origins)	Paraffin oil (placebo) 500 mg/d	12	BW,BMI,hs-CRP,QUICK,FPG, FINS, HOMA-IR, TG, TC, LDL-C, HDL-C,VLDL-C
Mohammadi 2012 [31]	Iran	Randomized, double blinded	Rotterdam criteria	30	31	n-3 PUFA supplements 4000 mg/d (720 mg EPA and 480 mg DHA) (Marine derived)	Paraffin oil (placebo) 500 mg/d	8	BW,BMI,WC,hs-CRP,FPG, FINS, HOMA-IR, TG, TC, LDL-C, HDL-C,Adiponectin
Nadjarzadeh 2015 [34]	Iran	Randomized, double blinded	Rotterdam criteria	39	39	n-3 PUFA supplements 1000 mg/d (180 mg EPA and 120 mg DHA)	Paraffin oil (placebo) 1000 mg/d	12	BMI,WC,Adiponectin
Rahmani 2017 [29]	Iran	Randomized, double blinded	Rotterdam criteria	34	34	Flaxseed oil n-3 PUFA 1000 mg/d (Plant origins) + Vitamin E 400 IU/d	Placebo	12	BW,BMI,TG, TC, LDL-C, HDL-C,VLDL-C
Talari 2018 [35]	Iran	Randomized, double blinded	Rotterdam criteria	30	30	Flaxseed oil n-3 PUFA 1000 mg/d (Plant origins) + Vitamin E 400 IU/d	Placebo	12	hs-CRP

Abbreviations: BW body weight, BMI body mass index, DHA docosahexaenoic acid, EPA eicosapentaenoic acid, FPG fasting plasma glucose, FINS fasting insulin, HDL-C high-density lipoprotein cholesterol, HOMA-IR homeostatic model of assessment for insulin resistance, hs-CRP high sensitivity C-reactive protein, LDL-C low-density lipoprotein cholesterol, n-3 PUFA n-3 polyunsaturated fatty acid, QUICK quantitative insulin sensitivity check index, TC total cholesterol, TG triglycerides, VLDL-C very low density lipoprotein-cholesterol

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ISSN: 1757-2215

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