Table 4 Univariate and multivariate analyses for PFS and OS based on TTC
| Â | PFS | OS | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
| Â | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | PÂ value |
Age, years | ||||||||
< 54 | 1 (Reference) |  | 1 (Reference) |  | 1 (Reference) |  | 1 (Reference) |  |
≥ 54 | 1.02 (0.85–1.23) | 0.827 | 0.94 (0.78–1.13) | 0.509 | 1.18 (0.93–1.49) | 0.175 | 1.04 (0.82–1.32) | 0.749 |
Type | ||||||||
Serous | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
Other | 1.24 (0.96–1.60) | 0.098 | 1.15 (0.87–1.52) | 0.326 | 1.15 (0.84–1.59) | 0.385 | 1.09 (0.77–1.55) | 0.613 |
Grade | ||||||||
Other | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
High | 1.25 (0.98–1.60) | 0.077 | 1.12 (0.85–1.47) | 0.418 | 1.06 (0.78–1.44) | 0.709 | 1.00 (0.72–1.39) | 0.985 |
FIGO Stage | ||||||||
IIIC | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
IV | 0.97 (0.80–1.17) | 0.741 | 0.88 (0.71–1.07) | 0.200 | 1.01 (0.79–1.30) | 0.935 | 0.91 (0.71–1.18) | 0.484 |
Upper abdominal surgery | ||||||||
No | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
Yes | 1.29 (0.97–1.72) | 0.083 | 1.27 (0.94–1.71) | 0.113 | 0.82 (0.54–1.26) | 0.377 | 0.80 (0.52–1.25) | 0.328 |
Bowel resection | ||||||||
No | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
Yes | 1.18 (0.91–1.54) | 0.209 | 1.09 (0.83–1.43) | 0.556 | 1.46 (1.06-2.00) | 0.02 | 1.36 (0.98–1.87) | 0.064 |
Lymphadenectomy | ||||||||
No | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
Yes | 0.73 (0.60–0.87) | 0.001 | 0.73 (0.60–0.88) | 0.001 | 0.72 (0.57–0.91) | 0.006 | 0.76 (0.59–0.97) | 0.030 |
Residual disease | ||||||||
R0 | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
R1 | 1.52 (1.24–1.87) | < 0.001 | 1.56 (1.26–1.92) | < 0.001 | 1.52 (1.16–1.99) | 0.002 | 1.51 (1.14–1.99) | 0.004 |
R2 | 1.61 (1.25–2.08) | < 0.001 | 1.55 (1.19–2.02) | 0.001 | 1.89 (1.37–2.59) | < 0.001 | 1.89 (1.35–2.64) | < 0.001 |
Postoperative complication | ||||||||
No | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â | 1 (Reference) | Â |
Yes | 1.26 (1.05–1.51) | 0.014 | 1.17 (0.97–1.42) | 0.100 | 1.44 (1.14–1.82) | 0.003 | 1.28 (1.00-1.63) | 0.050 |
NACT cycle | ||||||||
≤ 3 | 1 (Reference) |  | 1 (Reference) |  | 1 (Reference) |  | 1 (Reference) |  |
> 3 | 1.08 (0.86–1.36) | 0.509 | 1.21 (0.95–1.53) | 0.119 | 1.06 (0.79–1.42) | 0.714 | 1.15 (0.85–1.56) | 0.372 |
TTC | ||||||||
≤ 40 | 1 (Reference) |  | 1 (Reference) |  | 1 (Reference) |  | 1 (Reference) |  |
> 40 | 1.09 (0.90–1.3) | 0.376 | 1.07 (0.89–1.30) | 0.469 | 1.34 (1.06–1.69) | 0.016 | 1.34 (1.05–1.71) | 0.018 |