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Table 2 Primary and secondary outcomes between DHEA+ and DHEA - control groups

From: Dehydroepiandrosterone supplementation and the impact of follicular fluid metabolome and cytokinome profiles in poor ovarian responders

 

DHEA + group

DHEA- control group

Effect estimatea

p-value

(n = 28)

(n = 24)

(95% CI)

Clinical outcomes

 Clinical pregnancy, n (%)

2 (7.1)

3 (12.5)

0.57 (0.10–3.14)

0.652

 No. of oocytes retrieved, mean (SD)

5.2 (2.9)

4.5 (3.6)

0.7 (-1.4 to 2.9)

0.507

 No. of metaphase II oocytes, mean (SD)

4.0 (2.5)

3.5 (2.2)

0.6 (-1.0 to 2.1)

0.459

 No. of embryos, mean (SD)

2.7 (2.4)

2.3 (1.8)

0.4 (-1.1 to 1.8)

0.601

Embryos transferred, n (%)

 0

5 (23.8)

3 (17.7)

1

 

 1

9 (42.9)

5 (29.4)

1.03 (0.53 to 2.00)

1

 2

7 (33.3)

9 (52.9)

0.78 (0.44 to 1.39)

0.667

Hormonal outcomesb

 DHEA-S (µg/ml)

870.73 (96.00–3385.57)

182.45 (47.25–589.19)

4.77 (2.83 to 8.04)

 < 0.001

 Free Testosterone (pg/ml)

87.68 (19.54–457.86)

25.50 (11.56–202.89)

3.44 (2.12 to 5.59)

 < 0.001

 Estradiol (× 105) (pg/ml)

17.2 (6.15–137.00)

14.7 (2.15–32.5)

1.17 (0.67 to 2.02)

0.571

 AMH (ng/ml)

1.37 (0.21–12.60)

1.56 (0.39–6.12)

0.88 (0.45 to 1.70)

0.687

 IGF1 (ng/ml)

0.23 (0.01–18.84)

0.23 (0.08–14.22)

0.99 (0.37 to 2.63)

0.976

  1. aThe effect estimate refers to relative risk for clinical pregnancy, absolute mean difference for cycle outcomes and relative mean difference for hormonal biomarkers (ratio of geometric means)
  2. bHormones’ concentration in follicular fluid of the leading follicle, are summarized by geometric mean (range)