Table 4 List of identified follicular fluid metabolites

1

HMDB01859

151.0626

151.0633

Acetaminophen

C8H9NO2

Acetaminophen metabolism

2

HMDB04987

261.1206

261.1325

Alpha-Aspartyl-lysine

C10H19N3O5

Amino acid metabolism

3

HMDB03423/HMDB00641

146.0687

146.0691

D-Glutamine/L-Glutamine

C5H10N2O3

Amino acid metabolism

4

HMDB00714

179.0576

179.0582

Hippuric acid

C9H9NO3

Amino acid metabolism

5

HMDB00161/HMDB01310/ HMDB00271

89.0465

89.0477

L-Alanine/D-Alanine/Sarcosine

C3H7NO2

Amino acid metabolism

6

HMDB00641/HMDB03423

146.0687

146.0691

L-Glutamine/ D-Glutamine

C5H10N2O3

Amino acid metabolism

7

HMDB00687/HMDB00557/HMDB00172/HMDB01645

131.0941

131.0946

L-Leucine/L-Alloisoleucine/ L-Isoleucine/L-Norleucine

C6H13NO2

Amino acid metabolism

8

HMDB00696

149.0504

149.0510

L-Methionine

C5H11NO2S

Amino acid metabolism

9

HMDB00162

115.0629

115.0633

L-Proline

C5H9NO2

Amino acid metabolism

10

HMDB00883/HMDB00043

117.0784

117.0790

L-Valine/Betaine

C5H11NO2

Amino acid metabolism

11

HMDB00064/HMDB00766

131.0688

131.0695

Creatine/ N-Acetyl-L-alanine

C4H9N3O2

Arginine, proline, glycine and serine metabolism

12

HMDB00043/HMDB02141

117.0786

117.0790

Betaine/ N-Methyl-a-aminoisobutyric acid

C5H11NO2

Betaine Metabolism

13

HMDB01847

194.0796

194.0804

Caffeine

C8H10N4O2

Caffeine metabolism

14

HMDB01860

180.0642

180.0647

Paraxanthine

C7H8N4O2

Caffeine metabolism

15

HMDB02825

180.0638

180.0647

Theobromine

C7H8N4O2

Caffeine metabolism

16

HMDB00062

161.1048

161.1052

L-Carnitine

C7H15NO3

Fatty acid metabolism

17

HMDB00267/HMDB00805

129.0419

129.0426

Pyroglutamic acid/ Pyrrolidonecarboxylic acid

C5H7NO3

Glutathione metabolism

18

HMDB00017

183.0528

183.0532

4-Pyridoxic acid

C8H9NO4

Vitamin B6 metabolism

19

HMDB00995

312.2087

312.2089

16-Dehydroprogesterone

C21H28O2

Lipid metabolism

20

HMDB00502

388.2485

406.2719

3-Oxocholic acid

C24H38O5

Lipid metabolism

21

HMDB00308

356.2708

374.2821

3b-Hydroxy-5-cholenoic acid

C5H4N4O3

Lipid metabolism

22

HMDB00501

400.3339

400.3341

7-Ketocholesterol

C27H44O2

Lipid metabolism

23

HMDB00503

372.2659

390.2770

7a-Hydroxy-3-oxo-5b-cholanoic acid

C24H38O4

Lipid metabolism

24

HMDB00784

188.1041

188.1049

Azelaic acid

C9H16O4

Lipid metabolism

25

HMDB00015/HMDB01547

346.2131

346.2144

Cortexolone/Corticosterone

C21H30O4

Lipid metabolism

26

HMDB01547

346.2142

346.2144

Corticosterone

C21H30O4

Lipid metabolism

27

HMDB00063

362.2093

362.2093

Cortisol

C21H30O5

Lipid metabolism

28

HMDB00631

449.3131

449.3141

Deoxycholic acid glycine conjugate

C26H43NO5

Lipid metabolism

29

HMDB00573/HMDB03231

282.2564

282.2559

Elaidic acid/Vaccenic acid

C18H34O2

Lipid metabolism

30

HMDB00628/HMDB00234

288.2078

288.2089

Epitestosterone/Testosterone

C19H28O2

Lipid metabolism

31

HMDB00086

257.1026

257.1028

Glycerophosphocholine

C8H20NO6P

Lipid metabolism

32

HMDB00138

465.3096

465.3090

Glycocholic acid

C26H43NO6

Lipid metabolism

33

HMDB02259

270.2557

270.2559

Heptadecanoic acid

C17H34O2

Lipid metabolism

34

HMDB00666

130.0989

130.0994

Heptanoic acid

C7H14O2

Lipid metabolism

35

HMDB00689

116.0833

116.0837

Isocaproic acid

C6H12O2

Lipid metabolism

36

HMDB00673

280.2397

280.2402

Linoleic acid

C18H32O2

Lipid metabolism

37

HMDB00806

228.2088

228.2089

Myristic acid

C14H28O2

Lipid metabolism

38

HMDB00593

785.5943

785.5935

PC(18:1/18:1)

C44H84NO8P

Lipid metabolism

39

HMDB00847

158.1300

158.1307

Pelargonic acid

C9H18O2

Lipid metabolism

40

HMDB00253

316.2395

316.2402

Pregnenolone

C21H32O2

Lipid metabolism

41

HMDB01830

314.2239

314.2246

Progesterone

C21H30O2

Lipid metabolism

42

HMDB00792

202.1194

202.1205

Sebacic acid

C10H18O4

Lipid metabolism

43

HMDB00933

228.1335

228.1362

Traumatic acid

C12H20O4

Lipid metabolism

44

HMDB03231

282.2551

282.2559

Vaccenic acid

C18H34O2

Lipid metabolism

45

HMDB01877

144.1146

144.1150

Valproic acid

C8H16O2

Lipid metabolism

46

HMDB00876

384.3387

384.3392

Vitamin D3

C27H44O

Lipid metabolism

47

HMDB00182/HMDB03405

146.1048

146.1055

L-lysine/D-lysine

C6H14N2O2

Lysinuric protein intolerance

48

HMDB01923

230.0937

230.0943

Naproxen

C14H14O3

Naproxen action pathway

49

HMDB06344

264.1103

264.1110

Alpha-N-phenylacetyl-L-glutamine

C13H16N2O4

Phenylacetate Metabolism

50

HMDB00159

165.0784

165.1891

L-Phenylalanine

C9H11NO2

Phenylalanine metabolism

51

HMDB00097

103.0994

104.1075

Choline

C5H14NO

Phosphatidylcholine biosynthesis

52

HMDB00157

136.0380

136.0385

Hypoxanthine

C5H4N4O

Purine metabolism

53

HMDB00289

168.0278

168.0283

Uric acid

C5H4N4O3

Purine metabolism

54

HMDB00926

79.0421

79.0422

Pyridine

C5H5N

Pyridine biosynthesis

55

HMDB00975/HMDB00055

324.1052

342.1162

Trehalose/Cellobiose

C12H22O11

Pyrimidine metabolism

56

HMDB00300

112.0266

112.0273

Uracil

C4H4N2O2

Pyrimidine metabolism

57

HMDB00190/HMDB01311

90.0311

90.0317

L-Lactic acid/D-Lactic acid

C3H6O3

Pyruvate metabolism

58

HMDB00252

299.2818

299.2824

Sphingosine

C18H37NO2

Sphingolipid Metabolism

59

HMDB00374/HMDB00016/HMDB00920

330.2178

330.2195

17-Hydroxyprogesterone/ Deoxycorticosterone/11a-Hydroxyprogesterone

C21H30O3

Steroid biosynthesis

60

HMDB00929

204.0894

204.0899

L-Tryptophan

C11H12N2O2

Tryptophan metabolism

61

HMDB00197

175.0627

175.0633

Indoleacetic acid

C10H9NO2

Tryptophan metabolism

62

HMDB00183

208.0843

208.0848

L-Kynurenine

C10H12N2O3

Tryptophan metabolism

63

HMDB00158/HMDB06050

181.0735

181.0739

L-Tyrosine/o-Tyrosine

C9H11NO3

Tyrosine metabolism

64

HMDB02302

189.0782

189.0790

3-Indolepropionic acid

HMDB02302

Tryptophan deamination

65

HMDB01924

266.1620

266.1630

Atenolol

C14H22N2O3

Beta1-receptor inhibition

66

HMDB06115

106.0416

106.0419

Benzaldehyde

C7H6O

Oxidoreductase activity

67

HMDB00562

113.0586

113.0589

Creatinine

C4H7N3O

Arginine, proline, glycine and serine Metabolism/creatine catabolism

68

HMDB00453

114.0670

114.0681

Delta-hexanolactone

C6H10O2

Hydroxy acid lactonization

69

HMDB04983

94.0084

94.0089

Dimethyl sulfone

C2H6O2S

Methanethiol metabolism

70

HMDB01888

73.0524

73.0528

N,N-Dimethylformamide

C3H7NO

Tertiary carboxylic acid metabolism

71

HMDB00070

129.0785

129.0790

Pipecolic acid

C6H11NO2

Amino acid metabolism