Fig. 1

Identification of differentially expressed autophagy-related genes (DE-ATGs) in ovarian cancer (OV). A The flowchart of the study. B The heatmap of differential-expressed genes (DEGs) in normal and OV tissues of The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) dataset, among which the top 50 down-regulated genes and top 50 up-regulated genes were illustrated. C The volcano plot (top) of 6197 DEGs was constructed refer to adjust p-value and fold change values. The red dots indicate up-regulated genes, while the blue dots indicate downregulated genes (|log2(FC)|> 1 and adjust p-value < 0.01). The Venn diagram (bottom) showed the 52 significant differentially expressed autophagy-related genes (DE-ATGs). D The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) pathway enrichment analysis were performed to explore the functions of potential DE-ATGs. Here, the top 20 clusters were listed. E The protein–protein interaction (PPI) network diagram of the 52 DE-ATGs