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Table 3 Univariate and multivariate analysis of prognostic factors among 125 OV patients

From: A novel autophagy-related gene signature associated with prognosis and immune microenvironment in ovarian cancer

Characteristic

Univariate Analysis

Multivariate Analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Age

  < 55 years

Reference

-

Reference

-

  ≥ 55 years

0.937(0.552–1.591)

0.81

0.802(0.462–1.392)

0.432

FIGO stage

 I-II

Reference

-

Reference

-

 III-IV

3.042(1.570–5.895)

0.001

3.780(1.787–7.996)

0.001

Pathology stage

 I-II

Reference

-

Reference

-

 III

0.767(0.454–1.296)

0.322

0.710(0.393–1.284)

0.257

Histology type

 

0.829

 

0.193

 Serous

Reference

-

Reference

-

 Mucous

1.450(0.641–3.280)

0.372

3.001(0.976–9.221)

0.055

 Endometrioid

0.980(0.410–2.341)

0.963

0.990(0.397–2.471)

0.983

 Other types

1.143(0.563–2.321)

0.711

1.686(0.765–3.716)

0.195

Tumor diameter

  < 10 cm

Reference

-

Reference

-

  ≥ 10 cm

1.300(0.768–2.199)

0.329

1.312(0.739–2.328)

0.353

Serum CA125

  < 35 U/ml

Reference

-

Reference

-

  ≥ 35 U/ml

1.656(0.749–3.660)

0.213

1.459(0.538–3.954)

0.458

FOXO1 expression

 Low (H-score < 100)

Reference

-

Reference

-

 High (H-score ≥ 100)

1.892(1.113–3.214)

0.018

1.796(1.023–3.152)

0.041

  1. Abbreviation: HR hazard ratio, 95% CI 95% confidence interval, FIGO stage Federation of International of Gynecologists and Obstetricians stage, H-score Histochemistry score