Fig. 5

The effects of OXR and NK1R blockade on the relative expression of the steroidogenic genes in the EV-induced PCOS rats. (A) The expression of the Star gene and (B) The expression of the Cyp19a1 gene. The expression of target genes was normalized by the Gapdh gene in each sample. Star: steroidogenic acute regulatory protein, Cyp19a1: cytochrome P450 Family 19 Subfamily A Member 1, PCOS: polycystic ovary syndrome, OX1Ra: orexin-1 receptor antagonist, OX2Ra: orexin-2 receptor antagonist, NK1Ra: neurokinin-1 receptor antagonist. The data are presented as median (min, max). *P ≤ 0.05 and ^#P ≤ 0.05 compared to the control group by the Tukey’s test. ^$P ≤ 0.05 and ^&P ≤ 0.05 compared to the PCOS control group by the Tukey’s test