Fig. 3
From: BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing
Deletion of Bcas2 in granulosa cells impairs ovary development. A H&E staining of 7 dpp, 14 dpp, and 21 dpp ovaries from the PfGC-Bcas2−/− and PfGC-Bcas2−/− mice. The arrow indicates a primary follicle with an enlarged oocyte in PfGC-Bcas2−/− mice. The arrowhead indicates an atretic follicle in PfGC-Bcas2−/− mice. Black scale bars, 100 μm; white scale bars, 500 μm. B Quantitative analysis of follicle types from 7 dpp, 14 dpp, and 21 dpp mice in the PfGC-Bcas2+/+ and PfGC-Bcas2−/− ovaries. PrF, primordial follicles; PF, primary follicles; SF, secondary follicles; AF, antral follicles; APF, atretic follicles. Student’s t test was used for this study. Data are expressed as the means ± SEMs in at least three independent experiments. * P < 0.05, ** P < 0. 01, *** P < 0.001, **** P < 0.0001