Table 1 Clinical manifestations of the study patients
Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
|---|---|---|---|---|---|
Referral time | February 2014 | March 2017 | May 2017 | January 2019 | May 2019 |
Age, y | 29 | 28 | 31 | 29 | 28 |
Menarche | Spontaneous, 14 years | Spontaneous, 14 years | Spontaneous, 14 years | Primary amenorrhea | Spontaneous, 14 years |
Menses pattern | Regular cycle with menostaxis | Irregular cycle with menostaxis | Regular cycle | Irregular cycle | Irregular cycle with menostaxis |
Gynecological symptoms | Recurrent ovarian cysts | Recurrent ovarian cysts | None | None | Repeated endometrial cavity fluid and ovarian cysts |
Family history | A fertile brother, a twin sister with 17-OHD | No special | A fertile brother | A fertile sister, an unmarried brother | A sister with irregular menses |
Infertility type | Primary | Primary | Primary | Primary | Primary |
Duration of infertility, y | 7 | 4 | 7 | 3 | 6 |
Tubal patency assessment | Bilateral Patency | Bilateral Patency | Bilateral obstruction | Bilateral Patency | Bilateral Patency |
Hysteroscopy | Normal uterine cavity | Not examined | Normal uterine cavity | Not examined | Intrauterine adhesion |
Partner’s semen analysis | Normal | Normal | Normal | Normal | Normal |
Treatment experience before referral | Three cycles of IUI | Ovulation detection | Two IVF cycles | One IVF cycle | Misdiagnosis of PCOS, repeated hysteroscopy |
Height, cm | 158 | 163 | 162 | 168 | 168 |
Weight, kg | 63 | 56 | 64 | 54 | 64 |
BMI (kg/m2) | 25.24 | 21.08 | 24.39 | 19.13 | 22.68 |
Blood pressure (mmHg) | 121/76 | 110/77 | 120/77 | 100/73 | 106/67 |
Axillary hair | Sparse | No | No | No | No |
Tanner stage | B5PH2 | B5PH1 | B5PH2 | B5PH1 | B5PH1 |
Genitalia | Normal | Normal | Normal | Normal | Normal |
Karyotype | 46, XX | 46, XX | 46, XX | 46, XX | 46, XX |