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Table 1 Effects of Orlistat on body weight and Lee’s index in PCOS rats

From: Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

Group

Body mass

Lee’s index

0 weeks

4 weeks

8 weeks

12 weeks

16 weeks

Control

180.09 ± 8.75

251.13 ± 19.44**

312.54 ± 30.11**

309.46 ± 27.58**

349.53 ± 26.97**

3.08 ± 0.16*

PCOS

180.54 ± 7.81

316.60 ± 16.18

406.70 ± 25.18

435.97 ± 34.00

466.04 ± 32.81

3.21 ± 0.10

Low- Orlistat

179.97 ± 8.60

307.84 ± 28.22

379.21 ± 19.58*

408.28 ± 22.28*

433.35 ± 20.90*

3.11 ± 0.09*

Medium- Orlistat

179.83 ± 7.36

308.44 ± 22.08

375.92 ± 28.66*

405.68 ± 33.08*

425.75 ± 31.12**

3.09 ± 0.12*

High-Orlistat

180.29 ± 7.94

303.44 ± 18.09

372.59 ± 28.44**

390.93 ± 30.21**

409.00 ± 30.54**

3.08 ± 0.06*

  1. Values are the mean ± SD (n = 10/group)
  2. 0 weeks: PCOS modeling start time; 4 weeks: established PCOS model and start time point of Orlistat administration; 8 weeks: 4 weeks after Orlistat administration, and so on
  3. *p < 0.05
  4. **p < 0.01 compared with the PCOS group
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Journal of Ovarian Research

ISSN: 1757-2215

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