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Table 2 Effect of supplementation with orlistat on serum sex hormone and lipids levels in PCOS rats

From: Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

Group

Control

PCOS

Low- Orlistat

Medium- Orlistat

High-Orlistat

T (ng/ml)

1.51 ± 0.68*

4.83 ± 2.89

4.64 ± 2.49

3.10 ± 2.73

0.94 ± 0.72*

E2 (pg/ml)

14.40 ± 1.59**

2.47 ± 0.65

2.60 ± 0.84

2.99 ± 0.74

5.13 ± 0.29**

LH (mIU/ml)

5.18 ± 1.05*

7.03 ± 1.47

5.47 ± 1.06*

4.93 ± 0.93**

4.70 ± 1.49**

FSH (mIU/ml)

1.77 ± 0.32

1.71 ± 0.20

1.73 ± 0.31

1.76 ± 0.14

1.81 ± 0.46

LH/FSH

2.95 ± 0.29*

4.17 ± 1.19

3.33 ± 1.15

2.82 ± 0.66*

2.64 ± 0.74*

TC (mmol/L)

1.63 ± 0.29*

2.22 ± 0.50

1.72 ± 0.35

1.41 ± 0.48**

1.31 ± 0.22**

TG (mmol/L)

0.63 ± 0.11**

1.19 ± 0.34

0.84 ± 0.21*

0.70 ± 0.23**

0.65 ± 0.17**

LDL-C (mmol/L)

0.25 ± 0.03*

0.34 ± 0.06

0.25 ± 0.05*

0.24 ± 0.08**

0.21 ± 0.06**

HDL-C(mmol/L)

1.42 ± 0.16

1.30 ± 0.30

1.19 ± 0.23

1.02 ± 0.29

1.04 ± 0.19

  1. Values are the mean ± SD (N = 5–7). Data were analyzed by one-factor analysis of variance (ANOVA), followed by post-hoc the least significance difference (LSD)-t test
  2. Abbreviation: T Testosterone, E2 Estradiol, FSH Follicle stimulating hormone, LH luteinizing hormone, TC Total cholesterol, TG Triglycerides, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol
  3. *p < 0.05
  4. **p < 0.01 compared with the PCOS group