Table 1 Characteristics of the 14 studies in the meta-analysis
First Author | Year | Country | PCOS criteria | Age (Mean±SDPre/Post) | Number (Pre/Post) | BMI (Mean±SDPre/Post) | Study design | Dose(mg/ day) | Therapymonth | Method | AMH (mean±SD) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre | Post | |||||||||||
Piltonen | 2005 | Finland | Rotterdam | 21-41 | 26 | 18-41 | SCT | mean 1500 | 6 | EIA | 12.25±2.1 | 11.4±2.24 |
Bayrak | 2007 | USA | NIH | 29.5±4.8 | 10 | 30.2±4.5 | SCT | 850 | 1/4 | ELISA | 2.82±1.8 | 2.92±1.6 |
Carlsen | 2009 | Norway | Rotterdam | 30.6±5.9 | 20 | 33.4±7.5 | SCT | 2550 | 6 | ELISA | 15.3±11.5 | 15.2±12.0 |
Tomova-a | 2011 | Bulgaria | Rotterdam | NA | 13 | 33.8±2.76 Vs | SCT | 2550 | 6 | ELISA | 6.39±1.3 | 5.36±0.96 |
31.35±2.80 | ||||||||||||
Tomova-b | 2011 | Bulgaria | Rotterdam | NA | 4 | 22.08±1.12 Vs | SCT | 2550 | 6 | ELISA | 4.38±2.31 | 11.31±1.78 |
22.08±1.32 | ||||||||||||
Panidis | 2011 | Greece | NIH | 20.53±3.09 | 15 | 21.97±1.69 vs | SCT | 1700 | 6 | ELISA | 9.24±3.70 | 7.77±2.82 |
20.75±1.32 | ||||||||||||
Neagu | 2012 | Romania | AE/PCOS | NA | 11 | NA | SCT | gradually increase to 2550 | 2 | NA | 8.99±0.99 | 6.28.±0.46 |
Nascimento | 2013 | Brazil | Rotterdam | 26.3±1 | 16 | 29.1±1.7 | SCT | 1500 | 2 | ELISA | 6.99±0.85 | 5.81±0.78 |
Grigoryan-a | 2014 | Russia | Rotterdam | 28.7±5.2 | 18 | NA | SCT | 1700 | 6 | EIA | 8.1±1.8 | 6.9±1.6 |
Grigoryan-b | 2014 | Russia | Rotterdam | 28.7±5.2 | 22 | NA | SCT | 1700 | 6 | EIA | 7.7±1.4 | 7.9±1.6 |
Saleh | 2015 | Iraq | Rotterdam | 27.5±1.32 | 20 | 30.85±0.95 Vs | SCT | 1500 | 3 | ELISA | 4.49±0.54 | 3.03±0.53 |
29.01±1.01 | ||||||||||||
Foroozanfard | 2017 | Iran | Rotterdam | 25.2±4.2 | 30 | 26.2±3.8 | SCT | gradually increase to 1500 | 2 | ELISA | 10±3.75 | 7.8±3.7 |
Wiweko | 2017 | Indonesia | Rotterdam | 28.25±3.99 | 20 | 28.02±6.02Vs | SCT | 1500 | 6 | Beckman | 9.30±5.06 | 7.47±4.59 |
27.6±6.13 | Coulter gen II | |||||||||||
AMH assay | ||||||||||||
Chhabra | 2018 | India | Rotterdam | 30.03±3 | 32 | NA | SCT | 1700 | 3 | NA | 11.87±5.6 | 7.4±3.9 |