Fig. 5

Creation of a predictive risk score model. Results of the univariate Cox regression analysis of seven genes involved in the synthesis of steroid hormones are shown in A. B The frequency of mutations in 7 genes essential for the biosynthesis of steroid hormones in 518 EC patients from the TCGA cohort. C Analysis of mutation co-occurrence and selection for seven genes involved in the synthesis of steroid hormones. Co-occurrence is shown by the color green, whereas exclusion is indicated by the color brown. D The seven genes that contribute to the synthesis of steroid hormones’ LASSO coefficients. E Gene identification for the development of a predictive risk score model. A line represents a gene, and the end of these genes points to a vertical axis, which is the coefficient. F Principal component analysis of genes involved in the steroid hormone production pathway in EC. G Using the model genes (CYP7A1 and PPARGC1A) of steroid hormone biosynthesis pathway, principal component analysis was performed on the TCGA cohort to separate malignant tumors from control samples. The red group represented patients at high risk, while the blue group represented patients at low risk. *P < 0.01, •P < 0.05