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Fig. 8 | Journal of Ovarian Research

Fig. 8

From: Transcription factor c-fos induces the development of premature ovarian insufficiency by regulating MALAT1/miR-22-3p/STAT1 network

Fig. 8

Molecular mechanism of the c-fos-regulated MALAT1/miR-22-3p/STAT1 ceRNA network involved in POI development. Note: c-fos expression is increased in POI cells, and c-fos binds to the MALAT1 promoter region and promotes MALAT1 expression. MALAT1 acts as a ceRNA that competitively binds to miR-22-3p, reducing the targeting inhibitory effect of miR-22-3p on STAT1 and promoting STAT1 expression, ultimately leading to POI deterioration

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Journal of Ovarian Research

ISSN: 1757-2215

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