Development and validation of a nomogram to predict cancer-specific survival of mucinous epithelial ovarian cancer after cytoreductive surgery

Table 2 Univariate and multivariate Cox regression analysis of cancer-specific survival in the training cohort

Variable	Univariate Cox Regression			Multivariate Cox Regression
Variable	HR	95%CI	P-value	HR	95%CI	P-value
Age (yrs)
≤ 50	Reference			Reference
> 50	2.111	1.363–3.269	0.001	2.096	1.330–3.303	0.001
Marital status
Married	Reference			Reference
Other conditions	1.267	0.849–1.890	0.246	/	/	/
Differentiation			< 0.001			< 0.001
Well	Reference			Reference
Moderately	2.349	1.370–4.028	0.002	1.565	0.902–2.715	0.111
Poorly	8.765	5.118–15.010	< 0.001	3.941	2.188–7.101	< 0.001
CA125
Negative/Unknown	Reference			Reference
Positive	2.252	1.473–3.445	< 0.001	1.227	0.788–1.911	0.364
Tumor stage			< 0.001			< 0.001
IA-IB/ Localized	Reference			Reference		< 0.001
IC-IIB/ Regional	3.204	1.781–5.762	< 0.001	3.075	1.701–5.560	< 0.001
III-IV/ Distant	23.103	13.599–39.250	< 0.001	8.720	4.574–16.626	< 0.001
LNM
No/No resection	Reference			Reference
Positive	6.560	3.576–12.033	< 0.001	2.009	1.028–3.923	0.041
Residual Disease
R0	Reference			Reference		< 0.001
R1	7.263	4.180-12.619	< 0.001	2.536	1.360–4.728	0.003
R2	10.386	6.123–17.619	< 0.001	3.206	1.716–5.989	< 0.001

LNM lymph node metastasis, R0 no residual disease, R1 residual disease < 1 cm, R2 residual disease ≥ 1 cm

ISSN: 1757-2215