Fig. 3

The lesions of the fallopian tube and ovary in a patient with BRCA1 germline mutation

A, a single focus of occult high grade serous carcinoma localized in the right ovary (top left quadrangle)

B ~ D, the microscopic features from low power to high power. The tumor exhibited typical features of high grade serous carcinoma with papillary structures and markedly cellular atypia. Nuclei were large with nucleoli and mitoses were easily found (D)

E ~ H, high grade serous carcinoma was stained immunohistochemically with p53, PAX8, WT-1 and Ki-67 respectively. This case showed strong and diffuse expression of p53 (E) and moderate-high Ki-67 index (H)

I ~ J, STIC was found in the fimbriated end of the right tube (I) with strong and diffuse p53 staining (J). K ~ L, p53 signature was found in the left tube with focal strong p53 staining